COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS

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MOSAFER JAFAR; BAZRAFSHAN EDRIS

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Journal: Journal of Torbat Heydariyeh University of Medical Sciences Year:2017 | Volume:5 | Issue:3 Page(s): 39-47

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Title

COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS

Author(s)

MOSAFER JAFAR | BAZRAFSHAN EDRIS | Issue Writer Certificate

Keywords

NIGELLA SATIVAQ1

CURCUMA LONGAQ1

VITAMIN CQ1

OXIDATIVE STRESSQ1

Abstract

Background and Aim: The aim of this study was to compare the effects of hydro-alcoholic extract of CURCUMA LONGA (C.L E) and NIGELLA SATIVA (N.S E) with VITAMIN C on renal-oxidative damage in rats.Methods: 40 male Wistar rats were randomly divided into five groups (n=8) as follows: A Control group with plain drinking water and intervention groups including positive control groups with VITAMIN C (100 mg/kg), the N.S E (200 mg/kg) group, the C.L E (1000 mg/kg) group and N.S E and C.L E group (receiving 200 and 1000 mg/kg, respectively), all dissolved in drinking water and fed during the 35 days of the experiment. At the end of this period, the renal tissues were removed and oxidation-reduction markers were investigated.Results: N.S E (P<0.001), C.L E and VITAMIN C (P<0.01) decreased serum creatinine and BUN levels in comparison to the control group. Not only were the levels of total thiol higher in the VITAMIN C (P<0.001), N.S E, C.L E (P<0.05) and N.S E and C.L E (P<0.01) groups compared to the control group, but also the superoxide dismutase (SOD) activity was more elevated in VITAMIN C and N.S E and C.L E groups (P<0.01). Malondialdehyde (MDA) concentrations in the N.S E and C.L E, N.S E (P<0.001) and VITAMIN C (P<0.05) groups were lower than those in the control group.Conclusion: In the current study, it was found that N.S E and C.L E have a significant effect on the improvement of renal OXIDATIVE STRESS, which is comparable to VITAMIN C. A higher synergistic effect of N.S E and C.L E suggested that they are more effective combined than when used separately.

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APA: Copy

MOSAFER, JAFAR, & BAZRAFSHAN, EDRIS. (2017). COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 5(3 ), 39-47. SID. https://sid.ir/paper/244723/en

Vancouver: Copy

MOSAFER JAFAR, BAZRAFSHAN EDRIS. COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;5(3 ):39-47. Available from: https://sid.ir/paper/244723/en

IEEE: Copy

JAFAR MOSAFER, and EDRIS BAZRAFSHAN, “COMPARISON OF ANTIOXIDANT EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA WITH VITAMIN C ON RENAL TISSUE OXIDATIVE STRESS PARAMETERS IN RATS,” JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, vol. 5, no. 3 , pp. 39–47, 2017, [Online]. Available: https://sid.ir/paper/244723/en

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