THE EFFECT OF BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM ON ACQUISITION AND MOTOR MEMORY CONSOLIDATION

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SHAYAN NOOSHABADI ABOLFAZL; SABERI KAKHKI ALIREZA; SOHRABI MEHDI; DOWLATI MOHAMAD ALI

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:4 Page(s): 10-18

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Title

THE EFFECT OF BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM ON ACQUISITION AND MOTOR MEMORY CONSOLIDATION

Author(s)

SHAYAN NOOSHABADI ABOLFAZL | SABERI KAKHKI ALIREZA | SOHRABI MEHDI | DOWLATI MOHAMAD ALI | Issue Writer Certificate

Keywords

BRAIN-DERIVED NEUROTROPHIC FACTORQ2

POLYMORPHISMQ2

SINGLE NUCLEOTIDEQ2

LEARNINGQ2

Abstract

Introduction: Brain - derived neurotrophic factors (BDNF) play a role on induction and maintenance of memory and LEARNING. The BDNF gene Val66Met POLYMORPHISM impairs expression of this protein. Due to difference between the neural principles operating during motor memory consolidation and the neural principles operating during practice (acquisition) and the effect of BDNF on both of these processes, the aim of the study was to study the effect of val66met POLYMORPHISM on acquisition and motor memory consolidation in the process of LEARNING of throwing motor skill.Materials and Methods: We randomly selected one hundred university students of Kashan, Iran (mean age: 21.6±2.2 years). After blood sampling, extraction of genomic DNA, implementation of polymerase chain reaction, analyzing of PCR by 1.5 percent Electrophoresis Gel, and in the end sequencing by ABI PRISM 7000 Sequencing Analyzer, 46 participants were identified without val66met POLYMORPHISM, and 54 participants identified affected by the POLYMORPHISM (met - carriers).10 participants of each genetic group (20 people) after pre - test practiced backhand baseball pitch for six sessions.After 48 and 96 hours they participated in two consecutive retention tests.Results: Our data showed no difference between met- carriers and people without the POLYMORPHISM in acquisition and the first retention test. However, met - carriers were significantly weaker than people without the POLYMORPHISM in the second retention test.Conclusion: These findings suggest that the BDNF val66met POLYMORPHISM has higher impact on motor LEARNING in the consolidation phase than acquisition phase.

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APA: Copy

SHAYAN NOOSHABADI, ABOLFAZL, SABERI KAKHKI, ALIREZA, SOHRABI, MEHDI, & DOWLATI, MOHAMAD ALI. (2016). THE EFFECT OF BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM ON ACQUISITION AND MOTOR MEMORY CONSOLIDATION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(4), 10-18. SID. https://sid.ir/paper/257972/en

Vancouver: Copy

SHAYAN NOOSHABADI ABOLFAZL, SABERI KAKHKI ALIREZA, SOHRABI MEHDI, DOWLATI MOHAMAD ALI. THE EFFECT OF BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM ON ACQUISITION AND MOTOR MEMORY CONSOLIDATION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(4):10-18. Available from: https://sid.ir/paper/257972/en

IEEE: Copy

ABOLFAZL SHAYAN NOOSHABADI, ALIREZA SABERI KAKHKI, MEHDI SOHRABI, and MOHAMAD ALI DOWLATI, “THE EFFECT OF BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM ON ACQUISITION AND MOTOR MEMORY CONSOLIDATION,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 4, pp. 10–18, 2016, [Online]. Available: https://sid.ir/paper/257972/en

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