THE EFFECT OF TRICHOSTATIN A ON WORKING MEMORY AND SERUM BCL-2 LEVEL IN HYPOXIC-ISCHEMIA RAT MODEL

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KAHVAND ZAHRA; EDALATMANESH MOHAMMAD AMIN

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:4 Page(s): 35-40

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Title

THE EFFECT OF TRICHOSTATIN A ON WORKING MEMORY AND SERUM BCL-2 LEVEL IN HYPOXIC-ISCHEMIA RAT MODEL

Author(s)

KAHVAND ZAHRA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

HYPOXIAQ2

BRAINQ2

ISCHEMIAQ2

TRICHOSTATIN AQ2

Abstract

Introduction: Cerebral ISCHEMIA, occurs when a blood clot has occluded a BRAIN artery, is the third leading cause of mortality in the Western world. The present study was aimed to investigate the effects of TRICHOSTATIN A (TSA), a histone deacetylase inhibitor, on cognitive deficits and serum Bcl - 2 level in an animal model of HYPOXIA - ISCHEMIA rat model (HI).Materials and Methods: Thirty male Sprague dawley rats were randomly divided into the healthy control, HI+Saline and HI+TSA groups. The rats were suffered from the right common carotid artery ligation and 8% oxygen for 5 min to produce HI model. Two days after induction of ISCHEMIA, HI+TSA group received intraperitoneally TSA for 5 days. The Y maze test was used to assess the working memory. The ELISA test was performed to measure the serum Bcl- 2 level.Results: The results showed amelioration of working memory in HI+TSA group compared to HI+ Saline rats. In addition, a significant difference in the serum level of Bcl-2 was observed between HI+TSA and HI+ Saline groups.Conclusion: The data suggested TSA as a potential treatment for amelioration of cognitive deficits after BRAIN ISCHEMIA.

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References

THERAPEUTIC HYPOTHERMIA ACHIEVES NEUROPROTECTION VIA A DECREASE IN ACETYLCHOLINE WITH A CONCURRENT INCREASE IN CARNITINE IN THE NEONATAL HYPOXIA-ISCHEMIA

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APA: Copy

KAHVAND, ZAHRA, & EDALATMANESH, MOHAMMAD AMIN. (2016). THE EFFECT OF TRICHOSTATIN A ON WORKING MEMORY AND SERUM BCL-2 LEVEL IN HYPOXIC-ISCHEMIA RAT MODEL. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(4), 35-40. SID. https://sid.ir/paper/257980/en

Vancouver: Copy

KAHVAND ZAHRA, EDALATMANESH MOHAMMAD AMIN. THE EFFECT OF TRICHOSTATIN A ON WORKING MEMORY AND SERUM BCL-2 LEVEL IN HYPOXIC-ISCHEMIA RAT MODEL. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(4):35-40. Available from: https://sid.ir/paper/257980/en

IEEE: Copy

ZAHRA KAHVAND, and MOHAMMAD AMIN EDALATMANESH, “THE EFFECT OF TRICHOSTATIN A ON WORKING MEMORY AND SERUM BCL-2 LEVEL IN HYPOXIC-ISCHEMIA RAT MODEL,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 4, pp. 35–40, 2016, [Online]. Available: https://sid.ir/paper/257980/en

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