THE NEUROPROTECTIVE EFFECT OF SODIUM BUTYRATE ON SHORT-TERM MEMORY AND SERUM LEVEL OF B-CELL LYMPHOMA 2 IN A RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA

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SAHRAEIAN SAMIRA; EDALATMANESH MOHAMMAD AMIN

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Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:1 Page(s): 34-40

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Title

THE NEUROPROTECTIVE EFFECT OF SODIUM BUTYRATE ON SHORT-TERM MEMORY AND SERUM LEVEL OF B-CELL LYMPHOMA 2 IN A RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA

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SAHRAEIAN SAMIRA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

BRAIN ISCHEMIAQ2

MEMORYQ2

SHORT-TERMQ2

RATSQ2

Abstract

Introduction: Cerebral ischemic stroke is the third cause of death worldwide and is one of the main causes of long-term disabilities. Histone deacetylase inhibitors have effects on amelioration of brain disorders. The purpose of this study was to investigate the effects of sodium butyrate (SB) as a histone deacetylase inhibitor on SHORT-TERM working MEMORY and serum level of B-cell lymphoma 2 (Bcl2) protein in a rat cerebral hypoxic ischemia (HI) model.Materials and Methods: The animals were divided into 5 groups; control, HI+Saline, HI+SB 0.1, HI+SB 0.3, and HI+SB 0.6. Ischemia was induced by left carotid artery occlusion and then RATS were placed in the hypoxic chamber containing 8% oxygen for 5 minute. SB was injected at doses of 0.1, 0.3 and 0.6 (mg/kg/day) intra-peritonealy for 14 consecutive days in three treatment groups. SHORT-TERM working MEMORY in these groups was analyzed by Y-maze test. After performing the test, serum value of Bcl2 protein were measured by ELISA.Results: The percent of behavior alteration was higher in treatment groups than HI+Saline group in a dose dependent manner. In addition, SB administration reduced serum levels of Bcl2 in treatment groups.Conclusion: SB may cause amelioration of SHORT-TERM MEMORY and reduction of Bcl2 level, as an apoptosis marker, in cerebral hypoxic ischemia.

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APA: Copy

SAHRAEIAN, SAMIRA, & EDALATMANESH, MOHAMMAD AMIN. (2018). THE NEUROPROTECTIVE EFFECT OF SODIUM BUTYRATE ON SHORT-TERM MEMORY AND SERUM LEVEL OF B-CELL LYMPHOMA 2 IN A RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(1 ), 34-40. SID. https://sid.ir/paper/257986/en

Vancouver: Copy

SAHRAEIAN SAMIRA, EDALATMANESH MOHAMMAD AMIN. THE NEUROPROTECTIVE EFFECT OF SODIUM BUTYRATE ON SHORT-TERM MEMORY AND SERUM LEVEL OF B-CELL LYMPHOMA 2 IN A RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(1 ):34-40. Available from: https://sid.ir/paper/257986/en

IEEE: Copy

SAMIRA SAHRAEIAN, and MOHAMMAD AMIN EDALATMANESH, “THE NEUROPROTECTIVE EFFECT OF SODIUM BUTYRATE ON SHORT-TERM MEMORY AND SERUM LEVEL OF B-CELL LYMPHOMA 2 IN A RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 1 , pp. 34–40, 2018, [Online]. Available: https://sid.ir/paper/257986/en

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