Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESFANDIARI ZAHRA; EDALATMANESH MOHAMMAD AMIN

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:9 Page(s): 1864-1876

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

697

Download:

Cites:

Information Journal Paper

Title

Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model

Author(s)

ESFANDIARI ZAHRA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

Placental CirculationQ1

Brain Derived Neurotrophic FactorQ1

Gallic acidQ1

Entorhinal CortexQ1

RatQ2

Abstract

Introduction: Uteroplacental insufficiency (UPI) causes neurodevelopmental deficits affecting the intrauterine growth restricted (IUGR) offspring. This study aimed to analyze the effects of Gallic acid (GA) on memory deficit and brain-derived neurotrophic factor (BDNF) content in Entorhinal Cortex of UPI Rat models. Methods: In this experimental study, 40 pregnant Wistar Rats were randomly divided into 5 groups, including: control, UPI, UPI+GA100, UPI+GA200and UPI+GA400. For IUGR induction, anterior uterine artery occlusion surgery was carried out on gestation day (GD) 18. From GD15, GA was administRated orally, in 100, 200 and 400 mg/kg BW doses until the birth of their neonates. Spatial and working memories are analyzed by Morris water maze and Y maze at postnatal day (PND) 30, respectively. Then, BDNF cerebral cortex level was estimated using ELISA technique. The data were analyzed through ANOVA and Tukey Post hoc in SPSS software version 16. Results: A significant decrease was observed in spatial and working memories and BDNF content in Entorhinal Cortex of UPI group in comparison with the control group (p˂ 0. 05). On the other hand, GAtreated groups showed a significant increase in BDNF content and amelioRation of spatial and working memories (p˂ 0. 05). Conclusion: Fetal growth restrictionafter UPI by decreasingBDNFlevel in Entorhinal Cortex caused memory deficits in Rat’ s model. Moreover, neuroprotective effects of GA lead to increased BDNF content and amelioRate cognitive deficits in UPI model.

Cites

No record.

References

Cite

APA: Copy

ESFANDIARI, ZAHRA, & EDALATMANESH, MOHAMMAD AMIN. (2019). Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(9 ), 1864-1876. SID. https://sid.ir/paper/36390/en

Vancouver: Copy

ESFANDIARI ZAHRA, EDALATMANESH MOHAMMAD AMIN. Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(9 ):1864-1876. Available from: https://sid.ir/paper/36390/en

IEEE: Copy

ZAHRA ESFANDIARI, and MOHAMMAD AMIN EDALATMANESH, “Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 9 , pp. 1864–1876, 2019, [Online]. Available: https://sid.ir/paper/36390/en

Related Journal Papers