EVALUATION OF ANTICONVULSIVE EFFECT OF METHANOL EXTRACT OF FERULA ASAFOETIDA GUM IN MICE

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KARIMI MEHRDAD; NASERI MOHSEN; SAYYAH MOHAMMAD; KAMALINEJAD MOHAMMAD; AMIRI SEPIDEH

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:1 Page(s): 46-50

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Title

EVALUATION OF ANTICONVULSIVE EFFECT OF METHANOL EXTRACT OF FERULA ASAFOETIDA GUM IN MICE

Author(s)

Keywords

FERULAQ3

EPILEPSYQ2

MICEQ2

Abstract

Introduction: There are some reports on the antiepileptic effects of genus FERULA in the traditional Persian medicine. Due to the side effects of common antiepileptic drugs, effective compounds with fewer side effects are needed. The present study examined the anticonvulsive effects of the methanol extract of FERULA in seizures induced by maximum electroshock (MES) and pentylenetetrazol (PTZ) in MICE.Materials and Methods: Thirty minutes before the induction of seizures, sixty MICE were divided into six groups group I: solvent (10 mg/kg control group), group II: ethosuximide (150 mg/kg as positive control group for PTZ), group III: phenytoin (25 mg/kg as positive control group for MES) and the fourth, fifth, and sixth groups: the methanol extract of FERULA (100, 250, 500 mg/kg).Results: The methanol extract of FERULA did not inhibit the occurrence of seizures induced by PTZ and MES, but significantly increased the latency time in the PTZ model.Conclusion: It seems that the methanol extract of FERULA has different effects in various models of seizures and further investigation is needed.

Cites

THE EFFECT OF LIPOPOLYSACCHARIDE PRETREATMENT ON TRAUMA-INDUCED DARK NEURONS IN THE HIPPOCAMPUS

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APA: Copy

KARIMI, MEHRDAD, NASERI, MOHSEN, SAYYAH, MOHAMMAD, KAMALINEJAD, MOHAMMAD, & AMIRI, SEPIDEH. (2014). EVALUATION OF ANTICONVULSIVE EFFECT OF METHANOL EXTRACT OF FERULA ASAFOETIDA GUM IN MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(1), 46-50. SID. https://sid.ir/paper/258087/en

Vancouver: Copy

KARIMI MEHRDAD, NASERI MOHSEN, SAYYAH MOHAMMAD, KAMALINEJAD MOHAMMAD, AMIRI SEPIDEH. EVALUATION OF ANTICONVULSIVE EFFECT OF METHANOL EXTRACT OF FERULA ASAFOETIDA GUM IN MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(1):46-50. Available from: https://sid.ir/paper/258087/en

IEEE: Copy

MEHRDAD KARIMI, MOHSEN NASERI, MOHAMMAD SAYYAH, MOHAMMAD KAMALINEJAD, and SEPIDEH AMIRI, “EVALUATION OF ANTICONVULSIVE EFFECT OF METHANOL EXTRACT OF FERULA ASAFOETIDA GUM IN MICE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 1, pp. 46–50, 2014, [Online]. Available: https://sid.ir/paper/258087/en

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