THE EFFECT OF FERULA PERSICA L EXTRACTS, (SAKBINAG) ON SYMPTOMS OF MORPHINE WITHDRAWAL AND SLEEPING TIME IN MICE

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JADIDI MAJID; VAFAEI ABAS ALI; MILADI GORGI HOSSEIN; BABAEI SAEED ABADY AKRAM

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Journal: Research in Medicine Year:2010 | Volume:34 | Issue:4 Page(s): 225-230

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Title

THE EFFECT OF FERULA PERSICA L EXTRACTS, (SAKBINAG) ON SYMPTOMS OF MORPHINE WITHDRAWAL AND SLEEPING TIME IN MICE

Author(s)

JADIDI MAJID | VAFAEI ABAS ALI | MILADI GORGI HOSSEIN | BABAEI SAEED ABADY AKRAM | Issue Writer Certificate

Keywords

HYDRO ALCOHOLIC EXTRACTSQ2

FERULA PERSICAQ2

WITHDRAWAL SYNDROMEQ3

MORPHINEQ3

SLEEPING TIMEQ2

Abstract

Background: The genus Ferula (Apiaceae) is a perennial plant native to central Asia and is widespread throughout Iran, where it is used as food and also in traditional medicine. Several investigations on the Ferula species have shown analgesic, anti-inflammatory, antipyretic, and anticonvulsant effects in addition to smooth muscle relaxant activity. The aim of this study was to determine the effect of FERULA PERSICA on symptoms of MORPHINE withdrawal and SLEEPING TIME in mice.Methods: In this study, 64 male albino mice (25-30 g) were used. MORPHINE was used to produce drug dependency by Marshall Method (10 doses of drug in four days). For measuring SLEEPING TIME we used the Angle method. Hydro alcoholic extract of FERULA PERSICA (50, 100, 200 mg/kg IP) was injected to the experimental group and saline (10 ml/kg - IP) injected to the controls. The number of Jumping and amount of feces were used for assessment of classic signs of the WITHDRAWAL SYNDROME.Results: The results showed that the extract of FERULA PERSICA did not significantly affect the number of jumping but it decreased the stool weight (P=0.000). Also, extract of FERULA PERSICA significantly increased SLEEPING TIME (P=0.004).Conclusion: The extract of FERULA PERSICA may not affect WITHDRAWAL SYNDROME signs but it does increase the SLEEPING TIME.

Cites

THE EFFECTS OF ETHANOLIC EXTRACT OF DILL (ANETHUM GRAVEOLENS)) ON MORPHINE WITHDRAWAL SYMPTOMS IN ADDICTED MALE NMRI RATS

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APA: Copy

JADIDI, MAJID, VAFAEI, ABAS ALI, MILADI GORGI, HOSSEIN, & BABAEI SAEED ABADY, AKRAM. (2010). THE EFFECT OF FERULA PERSICA L EXTRACTS, (SAKBINAG) ON SYMPTOMS OF MORPHINE WITHDRAWAL AND SLEEPING TIME IN MICE. PAJOUHESH DAR PEZESHKI, 34(4), 225-230. SID. https://sid.ir/paper/41925/en

Vancouver: Copy

JADIDI MAJID, VAFAEI ABAS ALI, MILADI GORGI HOSSEIN, BABAEI SAEED ABADY AKRAM. THE EFFECT OF FERULA PERSICA L EXTRACTS, (SAKBINAG) ON SYMPTOMS OF MORPHINE WITHDRAWAL AND SLEEPING TIME IN MICE. PAJOUHESH DAR PEZESHKI[Internet]. 2010;34(4):225-230. Available from: https://sid.ir/paper/41925/en

IEEE: Copy

MAJID JADIDI, ABAS ALI VAFAEI, HOSSEIN MILADI GORGI, and AKRAM BABAEI SAEED ABADY, “THE EFFECT OF FERULA PERSICA L EXTRACTS, (SAKBINAG) ON SYMPTOMS OF MORPHINE WITHDRAWAL AND SLEEPING TIME IN MICE,” PAJOUHESH DAR PEZESHKI, vol. 34, no. 4, pp. 225–230, 2010, [Online]. Available: https://sid.ir/paper/41925/en

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