EFFECTS OF METHANOLIC EXTRACT OF ECHIUM AMOENUM FISCH & MEY ON SEIZURE INDUCED BY PICROTOXIN IN MICE

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HOSSEINI A.; SHARIATIFAR N.

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Journal: Internal Medicine Today Year:2004 | Volume:10 | Issue:2 Page(s): 20-25

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Title

EFFECTS OF METHANOLIC EXTRACT OF ECHIUM AMOENUM FISCH & MEY ON SEIZURE INDUCED BY PICROTOXIN IN MICE

Author(s)

HOSSEINI A. | SHARIATIFAR N. | Issue Writer Certificate

Keywords

ECHIUM AMOENUM; SEIZURE; PICROTOXIN; MICEQ3

Abstract

Background and Aim: The sedative effects of medicinal herbs of Echium Amoenum Fisch & Mey on nervous system have been known for many years. The aim of this study was to investigate the effects of methanolice extract of Echium amoenum Fisch & Mey against seizure induced by picrotoxin in mice. Materials and Methods: In this experiment study, in the first phase four groups of animals were pretreated by metabolic extract of this plant via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10mg/kg for the induction of seizure. Then lateney of onset time for the beginning of seizure, duration of seizure and mortality were determined. Data were subjected to the t test and chi-square test (P<0.05). Results: The results showed that latency of seizure was increased significantly in case groups that pretreated with different doses of extract (P<0.05) (especially 6.25 mg/kg). In addition, these doses delayed significantly the time death in mice (P<0.01). Conclusion: The extract of Echium Amoenum appears to be effective on seizure induced by picrotoxin in mice.

Cites

EFFECT OF PLANTING PATTERN AND PLANT DENSITY ON YIELD OF IRANIAN OXTONYUE (ECHIUM AMOENUM L.) IN THREE YEARS HARVESTING

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APA: Copy

HOSSEINI, A., & SHARIATIFAR, N.. (2004). EFFECTS OF METHANOLIC EXTRACT OF ECHIUM AMOENUM FISCH & MEY ON SEIZURE INDUCED BY PICROTOXIN IN MICE. OFOGH-E-DANESH, 10(2), 20-25. SID. https://sid.ir/paper/68477/en

Vancouver: Copy

HOSSEINI A., SHARIATIFAR N.. EFFECTS OF METHANOLIC EXTRACT OF ECHIUM AMOENUM FISCH & MEY ON SEIZURE INDUCED BY PICROTOXIN IN MICE. OFOGH-E-DANESH[Internet]. 2004;10(2):20-25. Available from: https://sid.ir/paper/68477/en

IEEE: Copy

A. HOSSEINI, and N. SHARIATIFAR, “EFFECTS OF METHANOLIC EXTRACT OF ECHIUM AMOENUM FISCH & MEY ON SEIZURE INDUCED BY PICROTOXIN IN MICE,” OFOGH-E-DANESH, vol. 10, no. 2, pp. 20–25, 2004, [Online]. Available: https://sid.ir/paper/68477/en

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