Pathogenic and Therapeutic Role of MicroRNAs in Glioblas toma Multiforme

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BABAZADEH SEYEDEH MALIHEH; Zolfaghary Mohammad Reza; SHIRIAN SADEGH; GHAEMI AMIR

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Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:8 | Issue:2 Page(s): 107-118

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Title

Pathogenic and Therapeutic Role of MicroRNAs in Glioblas toma Multiforme

Author(s)

BABAZADEH SEYEDEH MALIHEH | Zolfaghary Mohammad Reza | SHIRIAN SADEGH | GHAEMI AMIR | Issue Writer Certificate

Keywords

Glioblas tomaQ1

MicroRNAsQ1

Cell DeathQ2

Abstract

Introduction: Glioblas toma multiforme (GBM) is a severe type of brain tumors with very poor prognosis and a median survival time of about 15 months. To identify new biomarkers and therapeutic approaches, novel methods are crucial to treat GBM, based on the biological and molecular nature of these tumors. Recently, MicroRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, due to their emerging role in the regulation of cancer-related genes. miRNAs, a class of small non-coding RNA species, have vital roles across various biological processes, which may serve as diagnostic and prognos tic tools in GBM. Conclusion: This review indicated that miRNAs signatures could be used for developing new molecular therapies to enhance the survival of GBM patients. On the other hand, miRNAs regulate a wide range of cellular functions, allowing them to modulate many pathways critical to GBM progression, including proliferation, Cell Death, metastasis, angiogenesis, and drug resistance.

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APA: Copy

BABAZADEH, SEYEDEH MALIHEH, Zolfaghary, Mohammad Reza, SHIRIAN, SADEGH, & GHAEMI, AMIR. (2020). Pathogenic and Therapeutic Role of MicroRNAs in Glioblas toma Multiforme. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 8(2 ), 107-118. SID. https://sid.ir/paper/258166/en

Vancouver: Copy

BABAZADEH SEYEDEH MALIHEH, Zolfaghary Mohammad Reza, SHIRIAN SADEGH, GHAEMI AMIR. Pathogenic and Therapeutic Role of MicroRNAs in Glioblas toma Multiforme. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2020;8(2 ):107-118. Available from: https://sid.ir/paper/258166/en

IEEE: Copy

SEYEDEH MALIHEH BABAZADEH, Mohammad Reza Zolfaghary, SADEGH SHIRIAN, and AMIR GHAEMI, “Pathogenic and Therapeutic Role of MicroRNAs in Glioblas toma Multiforme,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 8, no. 2 , pp. 107–118, 2020, [Online]. Available: https://sid.ir/paper/258166/en

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