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Information Journal Paper

Title

INVES TIGATION OF CYTOTOXIC AND APOPTOGENIC EFFECTS OF TERMINALIA CHEBULA HYDRO-ALCOHOLIC EXTRACT ON GLIOBLAS TOMA CELL LINE

Pages

  14-23

Abstract

 Introduction: GLIOBLASTOMA multiforme is the most prevalent group of primary brain tumors. Terminalia chebula has traditionally been used for its anti-cancer, laxative, diuretic, and anti-oxidant properties. The aim of this study was to investigate the effects of alcoholic extract of Terminalia Chebula (TCAE) on the GLIOBLASTOMA multiforme (U87) cell line.Materials and Methods: Cellular cytotoxicity was measured by MTT assay and intracellular active oxygen species were measured using DCFDA (2 ‘and 7’-dichloro fluorescein diacetate) assay kit. In addition, apoptotic cells were detected with an Annexin V-FITC early APOPTOSIS staining.Results: TCAE reduced the proliferation of U87 cells in a concentration- dependent manner. IC50 was 145.3 and 192.3 mg/mL after 24 and 48 hours, respectively. Activated reactive species decreased significantly at 2 and 6 hours after treatment compared to the control group. Furthermore, induction of APOPTOSIS occurred in the first 24 hours.Conclusion: TCAE caused the destruction of cancer cells enhance the free radical species of oxygen and induce APOPTOSIS on GLIOBLASTOMA cell line. It seems that TCAE has the potential to use as an adjuvant drug for treatment of GLIOBLASTOMA.

Cites

References

Cite

APA: Copy

AFSHARI, AMIR REZA, KARIMI ROSHAN, MOSTAFA, SOUKHTANLOO, MOHAMMAD, ASKARI, VAHID REZA, MOLLAZADEH, HAMID, JALILI NIK, MOHAMMAD, JAHANI YAZDI, AMIR ALI, ARIA KIA, FATEMEH, & MOUSAVI, SEYED HADI. (2018). INVES TIGATION OF CYTOTOXIC AND APOPTOGENIC EFFECTS OF TERMINALIA CHEBULA HYDRO-ALCOHOLIC EXTRACT ON GLIOBLAS TOMA CELL LINE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(4 ), 14-23. SID. https://sid.ir/paper/258048/en

Vancouver: Copy

AFSHARI AMIR REZA, KARIMI ROSHAN MOSTAFA, SOUKHTANLOO MOHAMMAD, ASKARI VAHID REZA, MOLLAZADEH HAMID, JALILI NIK MOHAMMAD, JAHANI YAZDI AMIR ALI, ARIA KIA FATEMEH, MOUSAVI SEYED HADI. INVES TIGATION OF CYTOTOXIC AND APOPTOGENIC EFFECTS OF TERMINALIA CHEBULA HYDRO-ALCOHOLIC EXTRACT ON GLIOBLAS TOMA CELL LINE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(4 ):14-23. Available from: https://sid.ir/paper/258048/en

IEEE: Copy

AMIR REZA AFSHARI, MOSTAFA KARIMI ROSHAN, MOHAMMAD SOUKHTANLOO, VAHID REZA ASKARI, HAMID MOLLAZADEH, MOHAMMAD JALILI NIK, AMIR ALI JAHANI YAZDI, FATEMEH ARIA KIA, and SEYED HADI MOUSAVI, “INVES TIGATION OF CYTOTOXIC AND APOPTOGENIC EFFECTS OF TERMINALIA CHEBULA HYDRO-ALCOHOLIC EXTRACT ON GLIOBLAS TOMA CELL LINE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 4 , pp. 14–23, 2018, [Online]. Available: https://sid.ir/paper/258048/en

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