THE EVALUATION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND WORKING MEMORY IN VALPROIC ACID ANIMAL
MODEL OF AUTISM

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BORZOU ZAHRA; EDALATMANESH MOHAMMAD AMIN

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:4 Page(s): 10-16

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Title

THE EVALUATION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND WORKING MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM

Author(s)

BORZOU ZAHRA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

AUTISTIC DISORDERQ3

VALPROIC ACIDQ2

MEMORYQ2

SHORT-TERMQ2

Abstract

Introduction: Autism, a complex neurodevelopmental disorder, is characterized by social impairments, communication difficulties, as well as restricted, repetitive, and stereotyped patterns of behavior. Changes in serum level of brain-derived neurotrophic factor (BDNF) play a role in autism etiology. However, the serum levels and the mechanism of action of BDNF in autism are needed to be elucidated. Therefore, this study was aimed to determine the serum levels of BDNF and its relation with working MEMORY in VALPROIC ACID animal model of autism.Materials and Methods: Female Sprague Dawley rats were divided into two Phosphate-Buffered Saline receiver (PBS) and VALPROIC ACID receiver (VPA) groups. The pregnant rats were recieved VPA (500 mg/kg/ip) or PBS for 12.5 days after gestation. We evaluated the offspring in postnatal days 30 and 60. To measure changes in working MEMORY and the periodic behaviors of the animals, Y maze test was used. In addition, the serum levels of BDNF were determined by ELISA method.Results: Increased alteration behavior was observed in Y-maze test among offspring received VPA group compared to control rats. The serum levels of BDNF in VPA rats were significantly higher than PBS group.Conclusion: BDNF increases accompanied by enhancement of periodic behaviors in VPA rats suggested a crucial role of this protein in working MEMORY of autistic individuals.

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APA: Copy

BORZOU, ZAHRA, & EDALATMANESH, MOHAMMAD AMIN. (2015). THE EVALUATION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND WORKING MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(4), 10-16. SID. https://sid.ir/paper/258171/en

Vancouver: Copy

BORZOU ZAHRA, EDALATMANESH MOHAMMAD AMIN. THE EVALUATION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND WORKING MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(4):10-16. Available from: https://sid.ir/paper/258171/en

IEEE: Copy

ZAHRA BORZOU, and MOHAMMAD AMIN EDALATMANESH, “THE EVALUATION OF BRAIN DERIVED NEUROTROPHIC FACTOR AND WORKING MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 4, pp. 10–16, 2015, [Online]. Available: https://sid.ir/paper/258171/en

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