THE EVALUATION OF HIPPOCAMPAL LEVEL OF BRAIN DERIVED NEUROTROPHIC ‎FACTOR AND SPATIAL MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM

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BORZOU ZAHRA; EDALATMANESH MOHAMMAD AMIN

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2017 | Volume:27 | Issue:2 Page(s): 97-104

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Title

THE EVALUATION OF HIPPOCAMPAL LEVEL OF BRAIN DERIVED NEUROTROPHIC ‎FACTOR AND SPATIAL MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM

Author(s)

BORZOU ZAHRA | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

AUTISMQ1

VALPROIC ACIDQ1

BDNFQ1

SPATIAL MEMORYQ2

Abstract

Background: AUTISM, a behavior-developmental disorder, is characterized by impairments in social ‎interaction, communications, as well as restricted, repetitive, and stereotyped patterns of behavior. The ‎studies revealed changes in hippocampal level of brain-derived neurotrophic factor (BDNF) in AUTISM ‎etiology. However, their level and mechanism of action are needed to be elucidated. This study aimed ‎to determine the hippocampal levels of BDNF and its relation with SPATIAL MEMORY in VALPROIC ACID ‎animal model of AUTISM.Materials and methods:‎ In this experimental study, 40 male and female Sprague Dawley rat pups ‎were divided into two Phosphate-Buffered Saline receiver (PBS, n=20) and VALPROIC ACID receiver ‎‎(VPA, n=20) groups. VPA model of AUTISM was induced by intra-peritoneal administration of VPA ‎‎(500 mg/kg) at 12.5 days after gestation. To measure changes in SPATIAL MEMORY Morris water maze ‎test was used. Then, the hippocampal levels of BDNF were determined by ELISA method.Results: Increased SPATIAL MEMORY was observed in Morris water maze test among VPA group ‎compared to PBS group. In addition, the hippocampal levels of BDNF in VPA rats were significantly ‎higher than PBS group (p<0.05).Conclusion: Increasing BDNF showed enhancement of SPATIAL MEMORY in VPA rat model of AUTISM‎.

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APA: Copy

BORZOU, ZAHRA, & EDALATMANESH, MOHAMMAD AMIN. (2017). THE EVALUATION OF HIPPOCAMPAL LEVEL OF BRAIN DERIVED NEUROTROPHIC ‎FACTOR AND SPATIAL MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(2), 97-104. SID. https://sid.ir/paper/98579/en

Vancouver: Copy

BORZOU ZAHRA, EDALATMANESH MOHAMMAD AMIN. THE EVALUATION OF HIPPOCAMPAL LEVEL OF BRAIN DERIVED NEUROTROPHIC ‎FACTOR AND SPATIAL MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(2):97-104. Available from: https://sid.ir/paper/98579/en

IEEE: Copy

ZAHRA BORZOU, and MOHAMMAD AMIN EDALATMANESH, “THE EVALUATION OF HIPPOCAMPAL LEVEL OF BRAIN DERIVED NEUROTROPHIC ‎FACTOR AND SPATIAL MEMORY IN VALPROIC ACID ANIMAL MODEL OF AUTISM,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 2, pp. 97–104, 2017, [Online]. Available: https://sid.ir/paper/98579/en

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