EFFECT OF SEX AND AGE ON REPETITIVE, STEREOTYPED, AND EXPLORATORY BEHAVIORS IN A RAT MODEL OF VALPROIC ACID-INDUCED AUTISM

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RAFIEI SAMANEH; EDALATMANESH MOHAMMAD AMIN; REZAEI ELAHEH

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Journal: Neuroscience Journal of Shefaye Khatam Year:2017 | Volume:5 | Issue:3 Page(s): 11-17

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Title

EFFECT OF SEX AND AGE ON REPETITIVE, STEREOTYPED, AND EXPLORATORY BEHAVIORS IN A RAT MODEL OF VALPROIC ACID-INDUCED AUTISM

Author(s)

RAFIEI SAMANEH | EDALATMANESH MOHAMMAD AMIN | REZAEI ELAHEH | Issue Writer Certificate

Keywords

AUTISTIC DISORDERQ2

VALPROIC ACIDQ2

EXPLORATORY BEHAVIORQ2

Abstract

Introduction: Autism is characterized by behavioral impairments in social interaction, language and communication as well as restricted interests and activities. The present study examined stereotypical repetitive behaviors, anxiety, and locomotor as well as exploratory activities in rat model of VALPROIC ACID-induced autism.Materials and Methods: Pregnant Spraque dawley rats were administered by either VALPROIC ACID (VPA group, 500 mg/kg, n=10) or saline (control group, n=10) during fetal neural tube development on embryonic day 12.5. All male or female offspring were investigated in this study. Stereotypical and anxiety-exploratory behaviors were assessed using Y-maze and open field tests, respectively.Results: A single intra-peritoneal injection of VPA to pregnant rats produced severe autistic-like symptoms in the offspring. The results showed significant behavioral impairments including enhanced stereotyped repetitive behaviors, increased anxiety, and decreased exploratory activities in male rats at postnatal day 30 and 60 compared to female rats.Conclusion: Our data suggest that early embryonic exposure to VPA in rats provides an appropriate model for autism in male offspring.

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APA: Copy

RAFIEI, SAMANEH, EDALATMANESH, MOHAMMAD AMIN, & REZAEI, ELAHEH. (2017). EFFECT OF SEX AND AGE ON REPETITIVE, STEREOTYPED, AND EXPLORATORY BEHAVIORS IN A RAT MODEL OF VALPROIC ACID-INDUCED AUTISM. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 5(3), 11-17. SID. https://sid.ir/paper/258147/en

Vancouver: Copy

RAFIEI SAMANEH, EDALATMANESH MOHAMMAD AMIN, REZAEI ELAHEH. EFFECT OF SEX AND AGE ON REPETITIVE, STEREOTYPED, AND EXPLORATORY BEHAVIORS IN A RAT MODEL OF VALPROIC ACID-INDUCED AUTISM. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2017;5(3):11-17. Available from: https://sid.ir/paper/258147/en

IEEE: Copy

SAMANEH RAFIEI, MOHAMMAD AMIN EDALATMANESH, and ELAHEH REZAEI, “EFFECT OF SEX AND AGE ON REPETITIVE, STEREOTYPED, AND EXPLORATORY BEHAVIORS IN A RAT MODEL OF VALPROIC ACID-INDUCED AUTISM,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 5, no. 3, pp. 11–17, 2017, [Online]. Available: https://sid.ir/paper/258147/en

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