THE ROLE OF AMPA RECEPTOR IN THE BASOLATRAL AMYGDALA ON AGGRESSION AND ANXIETY IN RATS

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AHMADI MILAD; KARIMI GODARZI ALI; ALIZADEH LEILA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:1 Page(s): 57-64

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Title

THE ROLE OF AMPA RECEPTOR IN THE BASOLATRAL AMYGDALA ON AGGRESSION AND ANXIETY IN RATS

Author(s)

AHMADI MILAD | KARIMI GODARZI ALI | ALIZADEH LEILA | Issue Writer Certificate

Keywords

RECEPTORSQ3

AMPAQ3

AMYGDALAQ2

ANXIETYQ3

AGGRESSIONQ3

Abstract

Introduction: According to the previous studies, neural pathway of the basolatral AMYGDALA plays an important role in etiology and pathophysiology of depression, ANXIETY, and AGGRESSION. However, the exact role of the basolateral AMYGDALA in ANXIETY needs to be elucidated. Using social interaction and elevated plus maze tests, the role of AMPA glutamate subRECEPTORS in the basolatral AMYGDALA on AGGRESSION and ANXIETY-like behaviors was investigated.Materials and Methods: After anesthesia, two cannulas were implanted in the basolatral AMYGDALA in Wistar rats. After one week recovery, ANXIETY levels and different forms of AGGRESSION were analyzed by elevated plus maze and social interaction tests.Results: AMPA agonist was administered at 0.25, 0.5, and 1 mg/kg doses in the basolateral AMYGDALA. Doses of 0.5 and 1 mg/kg were significantly increased time spent in the open arms and offensive sideway compared to sham group. In addition, activation of AMPA receptor at 1 mg/kg significantly decreased the stay and entrance percentage of open arm and offensive sideway.Conclusion: Our data indicate that AMPA RECEPTORS modulate the signaling in the basolateral AMYGDALA and may affect ANXIETY and AGGRESSION.

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APA: Copy

AHMADI, MILAD, KARIMI GODARZI, ALI, & ALIZADEH, LEILA. (2015). THE ROLE OF AMPA RECEPTOR IN THE BASOLATRAL AMYGDALA ON AGGRESSION AND ANXIETY IN RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(1), 57-64. SID. https://sid.ir/paper/258202/en

Vancouver: Copy

AHMADI MILAD, KARIMI GODARZI ALI, ALIZADEH LEILA. THE ROLE OF AMPA RECEPTOR IN THE BASOLATRAL AMYGDALA ON AGGRESSION AND ANXIETY IN RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(1):57-64. Available from: https://sid.ir/paper/258202/en

IEEE: Copy

MILAD AHMADI, ALI KARIMI GODARZI, and LEILA ALIZADEH, “THE ROLE OF AMPA RECEPTOR IN THE BASOLATRAL AMYGDALA ON AGGRESSION AND ANXIETY IN RATS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 1, pp. 57–64, 2015, [Online]. Available: https://sid.ir/paper/258202/en

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