Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory

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RAHIMI TESIYE MARYAM; VALIZADEGAN FARHAD; ORYAN SHAHRBANOO

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2019 | Volume:22 | Issue:1 (137) Page(s): 73-84

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Title

Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory

Author(s)

RAHIMI TESIYE MARYAM | VALIZADEGAN FARHAD | ORYAN SHAHRBANOO | Issue Writer Certificate

Keywords

ApomorphineQ1

Basolateral AmygdalaQ1

ChloropromazineQ1

MorphineQ1

Prefrontal cortexQ1

Working memoryQ2

Abstract

Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amygdala (BLA). In this study, we investigated the role of Opioidergic system in medial PFC and Dopaminergic system of BLA nucleus in Working memory based on RAM test. Materials and Methods: In this study, The male Wistar rats were used. Rats were cannulated with stereotaxic surgery in mPFC and BLA sites. After a recovery period, they were microinjected. Parameters such as working and reference memory errors were calculated with DSWS protocol. Ethical Considerations: This study with research ethics code IR. UMZ. REC. 1397. 23 has been approved by Bioethics Committee at Mazandaran University, Iran. Findings: High doses of Morphine (2 μ g/rat) intra mPFC and Chloropromazine (2 μ g/rat) intra BLA have improving effects on working and reference memory (p≤ 0. 05). Low (0. 005 μ g/rat) and high dose (0. 5 μ g/rat) of Morphine/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ApoMorphine had improving {(p≤ 0. 05), (p≤ 0. 01)} and the moderate dose (0. 05 μ g/rat) of it had decreasing effect on working and reference memory (p≤ 0. 01). Microinjection of Morphine (0. 5 μ g/rat) with triple doses of Chloropromazine had no significant change on working and reference memory errors. Interaction of Morphine (0. 5 μ g/rat) with different doses of Morphine/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ApoMorphine could change Morphine/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ApoMorphine different effects. Coadministration of different doses of Morphine/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ApoMorphine with effective dose of Chloropromazine (2 μ g/rat) and Morphine (2 μ g/rat) decreased the working and reference memory errors. Conclusion: Our findings showed that in processing of working and reference memory, opioidergic system in mPFC and dopaminergic system in BLA, are interacting reciprocally.

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References

EVALUATION OF D1 AND D2 DOPAMINE RECEPTORS FAMILIES’ ROLE IN BASOLATERAL AMYGDALA ON WORKING AND REFERENCE MEMORY

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APA: Copy

RAHIMI TESIYE, MARYAM, VALIZADEGAN, FARHAD, & ORYAN, SHAHRBANOO. (2019). Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(1 (137) ), 73-84. SID. https://sid.ir/paper/69573/en

Vancouver: Copy

RAHIMI TESIYE MARYAM, VALIZADEGAN FARHAD, ORYAN SHAHRBANOO. Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(1 (137) ):73-84. Available from: https://sid.ir/paper/69573/en

IEEE: Copy

MARYAM RAHIMI TESIYE, FARHAD VALIZADEGAN, and SHAHRBANOO ORYAN, “Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 1 (137) , pp. 73–84, 2019, [Online]. Available: https://sid.ir/paper/69573/en

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