SYNTHESIS, CHARACTERIZATION, ANTITUMOR PROPERTIES, DNA-INTERACTION AND EFFECT OF ELECTRICAL CHARGES PRESENT ON DIFFERENT RATIOS OF PD (II):ZN (II) COMPLEXES IN THEIR

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MANSOURI TORSHIZI HASSAN; JAHANGIRY SAMIRA; BABAIE ZARCH MALIHE; KHODABAKHSHI KANGAN ZAHRA; NAZESHTI FARIDEH; HEIDARI MAJD MOSTAFA

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Journal: Nashrieh Shimi va Mohandesi Shimi Iran Year:2017 | Volume:36 | Issue:2 Page(s): 55-69

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Title

SYNTHESIS, CHARACTERIZATION, ANTITUMOR PROPERTIES, DNA-INTERACTION AND EFFECT OF ELECTRICAL CHARGES PRESENT ON DIFFERENT RATIOS OF PD (II):ZN (II) COMPLEXES IN THEIR "COMBINATION THERAPY"

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Keywords

PD (II) COMPLEXQ1

ZN (II) COMPLEXQ1

CYTOTOXICITYQ1

BINDING PARAMETERSQ1

THERMODYNAMIC PARAMETERSQ1

DNA-BINDINGQ1

Abstract

A modified literature procedure was used for synthesis [Pd(bpy)2](NO3)2, Pd(II), (where: bpy is 2, 2'-bipyridine ligand) and a new zinc complex of formula K[Zn(Gly)3], Zn(II), (where: Gly is glycinato ligand). These two complexes have been characterized by elemental analysis, conductivity measurements and spectroscopic techniques such as FT-IR, 1H NMR, and UV-Vis. Pd (II) complex alone and in presence of 1, 2 and 3 molar ratio of Zn (II) complex have been tested against Chronic myelocytic leukemia K562 cell lines. They show growth suppression activity. Thus calf thymus DNA-BINDING studies using UV-Vis methods were carried out. The results indicate that probably the planar aromatic moiety of the Pd (II) complex cooperatively intercalate in DNA and presence of Zn (II) complexes impede the intercalation by an unknown mechanism. The impeding properties of Zn (II) complex increases by increasing the ratio of Pd (II):Zn (II) ongoing from 1:1, 1:2 to 1:3. This might be due to the decrease in positive charges of the above mixtures ongoing from 1:1, 1:2 to 1:3 ratio (f. 1). We found no such an effect in the literature. In the process of the interaction studies, several binding and THERMODYNAMIC PARAMETERS were investigated.These parameters may be used to predict DNA-BINDING mechanism in the series.

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References

STUDIES OF THE INTERACTION OF NI (II) COMPLEXES BEARING PLANAR AROMATIC LIGANDS WITH CALF THYMUS DNA

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APA: Copy

MANSOURI TORSHIZI, HASSAN, JAHANGIRY, SAMIRA, BABAIE ZARCH, MALIHE, KHODABAKHSHI KANGAN, ZAHRA, NAZESHTI, FARIDEH, & HEIDARI MAJD, MOSTAFA. (2017). SYNTHESIS, CHARACTERIZATION, ANTITUMOR PROPERTIES, DNA-INTERACTION AND EFFECT OF ELECTRICAL CHARGES PRESENT ON DIFFERENT RATIOS OF PD (II):ZN (II) COMPLEXES IN THEIR "COMBINATION THERAPY". NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 36(2 ), 55-69. SID. https://sid.ir/paper/26398/en

Vancouver: Copy

MANSOURI TORSHIZI HASSAN, JAHANGIRY SAMIRA, BABAIE ZARCH MALIHE, KHODABAKHSHI KANGAN ZAHRA, NAZESHTI FARIDEH, HEIDARI MAJD MOSTAFA. SYNTHESIS, CHARACTERIZATION, ANTITUMOR PROPERTIES, DNA-INTERACTION AND EFFECT OF ELECTRICAL CHARGES PRESENT ON DIFFERENT RATIOS OF PD (II):ZN (II) COMPLEXES IN THEIR "COMBINATION THERAPY". NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2017;36(2 ):55-69. Available from: https://sid.ir/paper/26398/en

IEEE: Copy

HASSAN MANSOURI TORSHIZI, SAMIRA JAHANGIRY, MALIHE BABAIE ZARCH, ZAHRA KHODABAKHSHI KANGAN, FARIDEH NAZESHTI, and MOSTAFA HEIDARI MAJD, “SYNTHESIS, CHARACTERIZATION, ANTITUMOR PROPERTIES, DNA-INTERACTION AND EFFECT OF ELECTRICAL CHARGES PRESENT ON DIFFERENT RATIOS OF PD (II):ZN (II) COMPLEXES IN THEIR "COMBINATION THERAPY",” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 36, no. 2 , pp. 55–69, 2017, [Online]. Available: https://sid.ir/paper/26398/en

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