THE EFFECT OF VITAMIN A AND VITAMIN C ON POSTOPERATIVE ADHESION FORMATION: A RAT MODEL STUDY

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KELEIDARI BEHROUZ; MAHMOUDIEH MOHSEN; BAHRAMI FARANAK; MORTAZAVI PEJMAN; SARI ASLANI REZA; TOLIYAT SEYED ALIREZA

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2014 | Volume:18 | Issue:1 Page(s): 28-32

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Title

THE EFFECT OF VITAMIN A AND VITAMIN C ON POSTOPERATIVE ADHESION FORMATION: A RAT MODEL STUDY

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ADHESION FORMATIONQ4

VITAMIN AQ4

VITAMIN CQ4

Abstract

Background: The aim of this study is to investigate the effect of VITAMIN A and C, as the agents that improve wound healing, on the ADHESION FORMATION process.Materials and Methods: Sixty male Wistar rats were used. They underwent midline laparotomy, for repair of a peritoneal injury, and were then assigned to four groups. Group 1 (Vitamin A) received 2000 units/kg intramuscular injection of VITAMIN A daily, post surgery, for two weeks, Group 2 (Vitamin C) received 100 mg/kg oral VITAMIN C daily, after laparotomy, for two weeks, Group 3 (vitamins A and C) received 2000 units/kg intramuscular injection of VITAMIN A and 100 mg/kg oral VITAMIN C daily, after laparotomy, for two weeks, and Group four (Sham) rats did not receive any drugs. The adhesion, inflammation, fibrosis scores, and wound integrity were evaluated after two weeks.Results: Rats in the VITAMIN C group had the lowest mean ADHESION FORMATION score (1±0.27) and the values of p were<0.0001 for the VITAMIN A group and VITAMIN A and C groups and 0.003 for the sham group. VITAMIN C also had the lowest fibrosis score (0.50±0.17) among the study groups and the values of p were<0.0001 for the VITAMIN A group and VITAMIN A and C groups and 0.002 for the sham group. The mean inflammation score did not differ significantly among the study groups. The wound disruption strength was the highest in the VITAMIN C group and the difference was statistically significant in the sham group (1188.69±281.92 vs.893.04±187.46, p:0.003).Conclusion: Administration of oral VITAMIN C reduces ADHESION FORMATION and improves wound healing.

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APA: Copy

KELEIDARI, BEHROUZ, MAHMOUDIEH, MOHSEN, BAHRAMI, FARANAK, MORTAZAVI, PEJMAN, SARI ASLANI, REZA, & TOLIYAT, SEYED ALIREZA. (2014). THE EFFECT OF VITAMIN A AND VITAMIN C ON POSTOPERATIVE ADHESION FORMATION: A RAT MODEL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 18(1), 28-32. SID. https://sid.ir/paper/26676/en

Vancouver: Copy

KELEIDARI BEHROUZ, MAHMOUDIEH MOHSEN, BAHRAMI FARANAK, MORTAZAVI PEJMAN, SARI ASLANI REZA, TOLIYAT SEYED ALIREZA. THE EFFECT OF VITAMIN A AND VITAMIN C ON POSTOPERATIVE ADHESION FORMATION: A RAT MODEL STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2014;18(1):28-32. Available from: https://sid.ir/paper/26676/en

IEEE: Copy

BEHROUZ KELEIDARI, MOHSEN MAHMOUDIEH, FARANAK BAHRAMI, PEJMAN MORTAZAVI, REZA SARI ASLANI, and SEYED ALIREZA TOLIYAT, “THE EFFECT OF VITAMIN A AND VITAMIN C ON POSTOPERATIVE ADHESION FORMATION: A RAT MODEL STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 18, no. 1, pp. 28–32, 2014, [Online]. Available: https://sid.ir/paper/26676/en

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