CHANGES IN PARAMETERS RELATED TO SERUM IRON METABLOISM IN GALLIUM TREATED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOVAHEDIAN A.; MOSHTAGHI A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2000 | Volume:5 | Issue:Supplement 2 Page(s): 60-63

Download Full-Text

Persian Verion

View:

1,367

Download:

Cites:

Information Journal Paper

Title

CHANGES IN PARAMETERS RELATED TO SERUM IRON METABLOISM IN GALLIUM TREATED RATS

Author(s)

MOVAHEDIAN A. | MOSHTAGHI A.A. | Issue Writer Certificate

Keywords

GALLIUMQ4

IRONQ3

TRANSFERRINGQ4

METABOLISMQ4

Abstract

Background. GALLIUM (Ga) is used as radioimaging in diagnosis of cancers and also as a chemotherapeutic agent in the treatment of cancers. It is believed that GALLIUM may interfere with IRON METABOLISM and reduce cell growth in cancer tissues.Methods. GALLIUM as Ga-nitrate was injected daily to male rats. Animals were killed and sera were collected at indicated time. Serum IRON parameters were determined spectrophotometrically. TRANSFERRING in complex with Ga was isolated and purified using immunoaffinity chromatography techniques.Results. Data found from immunoaffinity technique showed that Ga in the serum was bound to TRANSFERRING, an IRON carrier protein. Daily administration of Ga (50mg/kg) as Ga-nitrate for 10 days reduced serum levels of IRON, TIBC, Hb and Hct by 57, 37, 30 and 29 percent respectively, suggesting the reduction of TRANSFERRING saturation by 30 percent. Significant reductions in the above parameters was also seen where Ga (10mg/kg) was injected daily for 30 and 60 days.Discussion. Results obtained from present study indicated that GALLIUM might be able to interfere with IRON METABOLISM. More investigation is needed to elucidate the exact mechanism by which GALLIUM undertakes its role in the cells with intercellular IRON biochemical pathways.

Cites

No record.

References

No record.

Cite

APA: Copy

MOVAHEDIAN, A., & MOSHTAGHI, A.A.. (2000). CHANGES IN PARAMETERS RELATED TO SERUM IRON METABLOISM IN GALLIUM TREATED RATS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 5(Supplement 2), 60-63. SID. https://sid.ir/paper/26735/en

Vancouver: Copy

MOVAHEDIAN A., MOSHTAGHI A.A.. CHANGES IN PARAMETERS RELATED TO SERUM IRON METABLOISM IN GALLIUM TREATED RATS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2000;5(Supplement 2):60-63. Available from: https://sid.ir/paper/26735/en

IEEE: Copy

A. MOVAHEDIAN, and A.A. MOSHTAGHI, “CHANGES IN PARAMETERS RELATED TO SERUM IRON METABLOISM IN GALLIUM TREATED RATS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 5, no. Supplement 2, pp. 60–63, 2000, [Online]. Available: https://sid.ir/paper/26735/en

Related Journal Papers