STUDY OF THE EFFECTS OF GALLIUM ON LIVER FUNCTION

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MOSHTAGHI A.A.; MOVAHEDIAN A.; GHARIPOUR M.

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Journal: Studies in Medical Sciences Year:2001 | Volume:12 | Issue:3 Page(s): 197-205

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Information Journal Paper

Title

STUDY OF THE EFFECTS OF GALLIUM ON LIVER FUNCTION

Author(s)

MOSHTAGHI A.A. | MOVAHEDIAN A. | GHARIPOUR M. | Issue Writer Certificate

Keywords

ALKALINE PHOSPHATASEQ4

GALLIUMQ4

LIVERQ4

Abstract

Introduction: GALLIUM is being used widely in radioimaing and chemotthapy for the treatment of many diseases including cancers. The accumulating of this element in LIVER has been reported previously. The present investigation the effects of GALLIUM on alkaline phasphatase activity and its isoenzymes as indexes for LIVER function has been studied. Material & Methods: Different groups of rat (5 in each group) were -choose and received GALLIUM (5, 10, 15 and 60 mg/kg) daily intraperitoneal for 10, 30 and 60 days. Animals were. Killed and sera were collected and loaded on the columns containing sephacryl S-300. High and low molecular weight (HMW, LMW) ALKP activities were determined.Results: Results obtained show that short time administration of GALLIUM for 10 days decreased ALKP activity for 15.86%, whereas daily administration of GALLIUM (5, 10 and 15mg/kg) daily for 30 days reduced the serum ALKP enzymes activity by 3.1, 10.7 and 21.9% respectively when injection of GALLIUM was carried out for 60 days these was a reduction of 10% and elevations enzyme activity by 10.7 and 33.48% respectively. Using gel filtration technique it was found that the elevation was due to HMW.Discussion: GALLIUM is able to make damage to hepatocyts and to the evaluated ALKP. More investigation should be done to detection the exact. mechanism.

Cites

EFFECTS OF GALLIUM ON BILIRUBIN AND AMINOTRANSFERASES IN RATS

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APA: Copy

MOSHTAGHI, A.A., MOVAHEDIAN, A., & GHARIPOUR, M.. (2001). STUDY OF THE EFFECTS OF GALLIUM ON LIVER FUNCTION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 12(3), 197-205. SID. https://sid.ir/paper/64133/en

Vancouver: Copy

MOSHTAGHI A.A., MOVAHEDIAN A., GHARIPOUR M.. STUDY OF THE EFFECTS OF GALLIUM ON LIVER FUNCTION. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2001;12(3):197-205. Available from: https://sid.ir/paper/64133/en

IEEE: Copy

A.A. MOSHTAGHI, A. MOVAHEDIAN, and M. GHARIPOUR, “STUDY OF THE EFFECTS OF GALLIUM ON LIVER FUNCTION,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 12, no. 3, pp. 197–205, 2001, [Online]. Available: https://sid.ir/paper/64133/en

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