COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER

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BORJIAN L.; RAHMANI A.R.

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2002 | Volume:7 | Issue:2 Page(s): 155-159

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Title

COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER

Author(s)

BORJIAN L. | RAHMANI A.R. | Issue Writer Certificate

Keywords

PEPTIC ULCERQ4

PREVENTIONQ2

STRESSQ4

ASPIRINQ4

CIMETIDINEQ4

QUINACRINEQ4

Abstract

Introduction. CIMETIDINE and QUINACRINE have protective effect on gastroduodenal lesions. In this study we compared efficacy of CIMETIDINE and QUINACRINE for PREVENTION of STRESS and ASPIRIN Induced PEPTIC ULCER.Methods. In an experimental studey, 36 rats randomly divided into 2 groups and each group divided into 3 subgroups of 6 rats. First subgroups of each group immersed in a water bath for 6 hours, or received ASA (250 mg/kg) orally with no prophylaxis (control groups). Second and third subgroups respectiely recieved QUINACRINE (30mg/kg) or CIMETIDINE (20mg/kg) one hour before induction of gastric lesion by water immersion or ASA Then the gastric mucosal lesions were assessed microscopically and marcroscopically.Results. Prophylaxis with CIMETIDINE and QUINACRINE both, significantly were effective (0<0.05) but better prophylactic effect of QUINACRINE was not statistically significant (P>0.05).Discussion. In conclusion, QUINACRINE and CIMETIDINE possess signifcant antiulcer and cytprotective activity against STRESS, and ASPIRIN induced gastric lesions.

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APA: Copy

BORJIAN, L., & RAHMANI, A.R.. (2002). COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(2), 155-159. SID. https://sid.ir/paper/26769/en

Vancouver: Copy

BORJIAN L., RAHMANI A.R.. COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2002;7(2):155-159. Available from: https://sid.ir/paper/26769/en

IEEE: Copy

L. BORJIAN, and A.R. RAHMANI, “COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRIN INDUCED PEPTIC ULCER,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. 2, pp. 155–159, 2002, [Online]. Available: https://sid.ir/paper/26769/en

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