Effects of Continuous Exercise Training in Accompany with H2O2 Injection on male rat Cardiac Bax, Bcl-2 and Bax/BCL-2 Ratio

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Safarzadeh Gargari Samad; MATIN HOMAI HASAN; AZARBAYJANI MOHAMMAD ALI

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Journal: JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY Year:2019 | Volume:5 | Issue:2 Page(s): 13-19

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Title

Effects of Continuous Exercise Training in Accompany with H2O2 Injection on male rat Cardiac Bax, Bcl-2 and Bax/BCL-2 Ratio

Author(s)

Safarzadeh Gargari Samad | MATIN HOMAI HASAN | AZARBAYJANI MOHAMMAD ALI | Issue Writer Certificate

Keywords

Cardiac cell apoptosis

BAX protein

BCL-2 protein

H2O2

Continues exercise

Abstract

Reactive oxygen species can induce cardiomyocytes apoptosis. But this mechanism has been unclear. The aim of this study was to investigate the effects of continuous exercise training on some of proteins involved in cardiac apoptosis (BAX, BCL-2) after the injection of H2O2 in different doses in male wistar rats. 50 males rats were randomly assigned into 5 groups with 10 rats in each group, including on Control (C),: injection of 1 (H1) and 2ml H2O2 (H2), exercise and injection of 1 (HE1) and 2 ml H2O2 (HE2) groups respectively. Exercising groups were running on a treadmill for eight weeks, four days per week. 24 hr after the last exercise session, all rats were sacrificed. Elisa technique was performed to determine cardiac tissue bax and bcl2 proteins level. The data were analyzed by ANOVA at level of p≤ 0/05. There were nonsignificant differences in cardiac BAX, BCL-2 and BAX/BCL2 ratio between groups. We concluded that participation in endurance training following to H2O2 injections at both doses may not lead to apoptosis induction in rats cardiomyocytes.

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APA: Copy

Safarzadeh Gargari, Samad, MATIN HOMAI, HASAN, & AZARBAYJANI, MOHAMMAD ALI. (2019). Effects of Continuous Exercise Training in Accompany with H2O2 Injection on male rat Cardiac Bax, Bcl-2 and Bax/BCL-2 Ratio. JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY, 5(2 ), 13-19. SID. https://sid.ir/paper/269306/en

Vancouver: Copy

Safarzadeh Gargari Samad, MATIN HOMAI HASAN, AZARBAYJANI MOHAMMAD ALI. Effects of Continuous Exercise Training in Accompany with H2O2 Injection on male rat Cardiac Bax, Bcl-2 and Bax/BCL-2 Ratio. JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY[Internet]. 2019;5(2 ):13-19. Available from: https://sid.ir/paper/269306/en

IEEE: Copy

Samad Safarzadeh Gargari, HASAN MATIN HOMAI, and MOHAMMAD ALI AZARBAYJANI, “Effects of Continuous Exercise Training in Accompany with H2O2 Injection on male rat Cardiac Bax, Bcl-2 and Bax/BCL-2 Ratio,” JOURNAL OF APPLIED HEALTH STUDIES IN SPORT PHYSIOLOGY, vol. 5, no. 2 , pp. 13–19, 2019, [Online]. Available: https://sid.ir/paper/269306/en

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