Effects of continues exercise on BAX and BCL-2 heart proteins following by different dos of H2O2 consumption in rat male

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Safarzadeh Gargari Samad; Matin Homai Hassan; AZARBAYJANI MOHAMMAD ALI

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:4 Page(s): 363-379

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Title

Effects of continues exercise on BAX and BCL-2 heart proteins following by different dos of H2O2 consumption in rat male

Author(s)

Safarzadeh Gargari Samad | Matin Homai Hassan | AZARBAYJANI MOHAMMAD ALI | Issue Writer Certificate

Keywords

Cardiac cell apoptosisQ1

BAX proteinQ1

BCL-2 proteinQ2

H2O2Q1

Continues exerciseQ2

RatQ2

Abstract

Introdution: The research has been indicated that reactive oxygen species induced the apoptosis of cardiomyocytes. However, this mechanism has been unclear. The aim of this study was to investigate the effects of concurrent training on some of the heart apoptosis variables (BAX, BCL-2) following by the injection of different H2O2 dose in Wistar Rat males. Methods: 50 male Rats were randomly assigned to 5 groups with 10 Rats in which group. Groups included: group (1): control group (C), group (2, 3): injection of 1 and 2ml H2O2, group (4, 5): exercise and injection of 1and 2 ml H2O2. Exercise groups have been run on treadmill for four days during 8 weeks at modeRate intensity. 24 hr after the last exercise and in anesthetic state all Rats have been knockouted to determine bax and bcl2 proteins Ratio. For measuring the BAX and BCL-2 proteins were used by ELISA technic and total protein were determined by brad ford technic. Data were analyzed by SPSS 17, one ways ANOVA was used to analysis of data at the level of p≤ 0/05. Results: The results have been indicated that after two month continues training no significant difference in BAX, BCL-2 proteins and BAX/BCL2 Ratio in exercise and H2O2 groups in compared by control groups. Conclusion: based on the result of this study if the 8-week continues training has been followed by H2O2 injection with both of one and two ml H2O2 concentRation, it may not have induced apoptosis cardio myocyte in Rats. And it may adjusted the synthesis and degradation myocardial.

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APA: Copy

Safarzadeh Gargari, Samad, Matin Homai, Hassan, & AZARBAYJANI, MOHAMMAD ALI. (2018). Effects of continues exercise on BAX and BCL-2 heart proteins following by different dos of H2O2 consumption in rat male. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(4 ), 363-379. SID. https://sid.ir/paper/36193/en

Vancouver: Copy

Safarzadeh Gargari Samad, Matin Homai Hassan, AZARBAYJANI MOHAMMAD ALI. Effects of continues exercise on BAX and BCL-2 heart proteins following by different dos of H2O2 consumption in rat male. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(4 ):363-379. Available from: https://sid.ir/paper/36193/en

IEEE: Copy

Samad Safarzadeh Gargari, Hassan Matin Homai, and MOHAMMAD ALI AZARBAYJANI, “Effects of continues exercise on BAX and BCL-2 heart proteins following by different dos of H2O2 consumption in rat male,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 , pp. 363–379, 2018, [Online]. Available: https://sid.ir/paper/36193/en

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