مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DIVERSITY OF MEROZOITE SURFACE PROTEIN-3BETA GENE OF PLASMODIUM VIVAX ISOLATES FROM IRAN

Pages

  1-5

Abstract

 Background: PLASMODIUM VIVAX malaria accounts for approximately 88% of malaria cases in IRAN. There is limited information on genetic diversity of P. vivax in the country and a need to develop and apply an effective vaccine against the disease is necessary. Among many potential candidates, MSP -3b gene is promising target. This study was designed and carried out to determine the variation of this gene as genetic marker in population of malarious areas of IRAN. Methods: Blood sample of 85 P. vivax isolates from four southern and east-southern provinces of the country assessed for polymorphism of PvMSP-3b gene by PCR/RFLP method. Results: Based on the size of PCR product of the gene, 7 genetically different types of parasite has been distinguished. Two alleles were simultaneously visible in 19 % of the cases. Results from PCR/RFLP analysis of PvMSP-3b gene showed at least 15 allelic groups. Multiple infections have been found in 2.4 % of the cases. Conclusion: PvMSP-3b gene was highly diverse in P. vivax isolates of malarious areas of IRAN, and can be a suitable marker for population genetic studies of P. vivax. More investigations on PvMSP-3b genes are needed to reveal genetic structure of P. vivax in IRAN.

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    • Cite

    APA: Copy

    SHAHBAZI, A., RAEISI, A., NATEGHPOUR, M., MIRHENDI, H., MOHEBALI, M., & ASMAR, M.. (2007). DIVERSITY OF MEROZOITE SURFACE PROTEIN-3BETA GENE OF PLASMODIUM VIVAX ISOLATES FROM IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 36(4), 1-5. SID. https://sid.ir/paper/272459/en

    Vancouver: Copy

    SHAHBAZI A., RAEISI A., NATEGHPOUR M., MIRHENDI H., MOHEBALI M., ASMAR M.. DIVERSITY OF MEROZOITE SURFACE PROTEIN-3BETA GENE OF PLASMODIUM VIVAX ISOLATES FROM IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2007;36(4):1-5. Available from: https://sid.ir/paper/272459/en

    IEEE: Copy

    A. SHAHBAZI, A. RAEISI, M. NATEGHPOUR, H. MIRHENDI, M. MOHEBALI, and M. ASMAR, “DIVERSITY OF MEROZOITE SURFACE PROTEIN-3BETA GENE OF PLASMODIUM VIVAX ISOLATES FROM IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 36, no. 4, pp. 1–5, 2007, [Online]. Available: https://sid.ir/paper/272459/en

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