THE SPECTRUM OF BETA -THALASSEMIA MUTATIONS IN ISFAHAN PROVINCE OF IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DERAKHSHANDEH PEYKAR P.; HOUR FAR H.; HEYDARI M.; KHEYR ELAHI M.; MIR YOUNESI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2008 | Volume:37 | Issue:2 Page(s): 106-111

Download Full-Text

View:

464

Download:

347

Cites:

Information Journal Paper

Title

THE SPECTRUM OF BETA -THALASSEMIA MUTATIONS IN ISFAHAN PROVINCE OF IRAN

Author(s)

Keywords

BETA -THALASSEMIA

BETA-GLOBIN MUTATION

REVERSE DOT BLOT

ISFAHAN

IRAN

Abstract

Background: b-thalassemia is a common autosomal recessive disorder resulting from over 200 different mutations of beta globin genes. The aim of the present study was to identify the distribution and frequency of the most common b-thalassemia mutations among the population of ISFAHAN Province in central IRAN.Methods: The data presented here were derived from a total of 114 b-thalassemia chromosomes of 18 affected patients and 78 unrelated carriers identified in our screening program. Furthermore, 23 pregnant women were analyzed among couples with a PND request for b-thalassemia. Allele identification was carried out using routine REVERSE DOT BLOT, ARMS, and genomic sequencing.Results: The most common mutation, IVS-II-I, followed by FSC-36-37, IVS-I-5, FSC-8-9, IVS-I-110, IVS-I,3’-end; -25bp, IVS-II-745, FSC-8, Cd-39, FSC-22-24, IVS-I-1, Cd-44, IVSII-2,3 (+11/-2), IVS-I-6, and FSC-16, respectively. The present study not only provides a guide for distribution and frequency of both recurrent and uncommon mutations, but also for the first time, reports a rare b-thalassemia mutation, IVSII-2, 3 (+11/-2), in the ISFAHAN province of IRAN.Conclusion: The information presented here could greatly facilitate screening for b-thalassemia and prenatal diagnosis in the province of ISFAHAN.

Cites

TETRA-PRIMER ARMS PCR OPTIMIZATION FOR DETECTION OF IVS-II-I (G-A) AND FSC 8/9 INSG MUTATIONS IN β -THALASSEMIA MAJOR PATIENTS IN ISFAHAN POPULATION

References

Cite

APA: Copy

DERAKHSHANDEH PEYKAR, P., HOUR FAR, H., HEYDARI, M., KHEYR ELAHI, M., & MIR YOUNESI, M.. (2008). THE SPECTRUM OF BETA -THALASSEMIA MUTATIONS IN ISFAHAN PROVINCE OF IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 37(2), 106-111. SID. https://sid.ir/paper/272512/en

Vancouver: Copy

DERAKHSHANDEH PEYKAR P., HOUR FAR H., HEYDARI M., KHEYR ELAHI M., MIR YOUNESI M.. THE SPECTRUM OF BETA -THALASSEMIA MUTATIONS IN ISFAHAN PROVINCE OF IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2008;37(2):106-111. Available from: https://sid.ir/paper/272512/en

IEEE: Copy

P. DERAKHSHANDEH PEYKAR, H. HOUR FAR, M. HEYDARI, M. KHEYR ELAHI, and M. MIR YOUNESI, “THE SPECTRUM OF BETA -THALASSEMIA MUTATIONS IN ISFAHAN PROVINCE OF IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 37, no. 2, pp. 106–111, 2008, [Online]. Available: https://sid.ir/paper/272512/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops