COMPARISON OF SERUM LEPTIN LEVELS OF NON-DIABETIC AND DIABETIC OBESE SUBJECTS AND ITS RELATIONSHIP TO ANTHROPOMETRIC INDICES

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MOHAMMADZADEH GH.; ZARGHAMI N.A.; ZAHEDIASL S.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2008 | Volume:10 | Issue:4 (SN 40) Page(s): 353-362

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Title

COMPARISON OF SERUM LEPTIN LEVELS OF NON-DIABETIC AND DIABETIC OBESE SUBJECTS AND ITS RELATIONSHIP TO ANTHROPOMETRIC INDICES

Author(s)

MOHAMMADZADEH GH. | ZARGHAMI N.A. | ZAHEDIASL S. | Issue Writer Certificate

Keywords

TYPE 2 DIABETESQ2

OBESITYQ2

LEPTINQ2

BMIQ3

Abstract

Introduction: LEPTIN, the product of the ob gene, plays a significant role in the pathogenesis of OBESITY and TYPE 2 DIABETES mellitus. The aim of this study was to compare serum LEPTIN level in non-diabetic and type 2 diabetic obese subjects and assess its relationship to anthropometric indices. Material and Methods: This cross-sectional study was performed on 35 obese subjects with TYPE 2 DIABETES and 35 non-obese, non-diabetics. Fasting lipid profiles were measured using enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c. Serum LEPTIN, insulin and glucose levels were measured by an enzyme immunoassay, using a commercially available kit and glucose oxidase methods respectively. The insulin resistance index was calculated by homeostasis model assessment (HOMA-IR). Results: The mean of insulin resistance index (HOMAIR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetics were significantly higher than in non-diabetic subjects (P < 0.05). Serum LEPTIN levels were significantly lower in diabetics than in non-diabetics (21.51±2.18 vs. 30.36±2.46) and were significantly higher in women than in men (31.85±17.96 vs.12.80±9.02) in the diabetic and (36.11±10.99 vs. 23.55±15.72) in nondiabetic groups. There was a direct and significant correlation between serum LEPTIN levels with hip circumference (r= 0.450, p= 0.04) in diabetics and (r=0.590, p=0.000) in non-diabetics, and between LEPTIN and BMI (r= 0.666, p= 0.000) in diabetic and (r= 0.490, p= 0.003) in non-diabetic groups. Conclusion: Since the mean serum LEPTIN level is lower in obese diabetes, compared to nondiabetics, further studies are required to clarify the mechanisms of lower LEPTIN levels in obese diabetic subjects.

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APA: Copy

MOHAMMADZADEH, GH., ZARGHAMI, N.A., & ZAHEDIASL, S.. (2008). COMPARISON OF SERUM LEPTIN LEVELS OF NON-DIABETIC AND DIABETIC OBESE SUBJECTS AND ITS RELATIONSHIP TO ANTHROPOMETRIC INDICES. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(4 (SN 40)), 353-362. SID. https://sid.ir/paper/27410/en

Vancouver: Copy

MOHAMMADZADEH GH., ZARGHAMI N.A., ZAHEDIASL S.. COMPARISON OF SERUM LEPTIN LEVELS OF NON-DIABETIC AND DIABETIC OBESE SUBJECTS AND ITS RELATIONSHIP TO ANTHROPOMETRIC INDICES. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;10(4 (SN 40)):353-362. Available from: https://sid.ir/paper/27410/en

IEEE: Copy

GH. MOHAMMADZADEH, N.A. ZARGHAMI, and S. ZAHEDIASL, “COMPARISON OF SERUM LEPTIN LEVELS OF NON-DIABETIC AND DIABETIC OBESE SUBJECTS AND ITS RELATIONSHIP TO ANTHROPOMETRIC INDICES,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 4 (SN 40), pp. 353–362, 2008, [Online]. Available: https://sid.ir/paper/27410/en

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