PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX

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JALILIAN A.R.; ROUSHAN FARZAD P.; RAHIMINEJAD-KISOMI A.; MORADKHANI S.; MOTAMEDI SADEH F.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2004 | Volume:12 | Issue:3 Page(s): 115-122

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Title

PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX

Author(s)

Keywords

ZINC-65

BLEOMYCINS

BIODISTRIBUTION

EUGER EMITTERS

CYCLOTRON

Abstract

Bleomycin (BLM) has been labeled with various radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [65Zn] zinc chloride and its distribution and stability in normal and tumor bearing mice was determined. The complex was obtained at the pH=2 in normal saline at 90 °C in 60 minutes. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity >97%).The in vitro stability of the complex was determined in mice and human plasma. Preliminary studies were performed to determine distribution of [65Zn]BLM in normal and tumor bearing mice on the basis of these results. [65Zn]BLM may be used in therapeutic studies due to its suitable physico-chemical properties.

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APA: Copy

JALILIAN, A.R., ROUSHAN FARZAD, P., RAHIMINEJAD-KISOMI, A., MORADKHANI, S., & MOTAMEDI SADEH, F.. (2004). PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 12(3), 115-122. SID. https://sid.ir/paper/275217/en

Vancouver: Copy

JALILIAN A.R., ROUSHAN FARZAD P., RAHIMINEJAD-KISOMI A., MORADKHANI S., MOTAMEDI SADEH F.. PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2004;12(3):115-122. Available from: https://sid.ir/paper/275217/en

IEEE: Copy

A.R. JALILIAN, P. ROUSHAN FARZAD, A. RAHIMINEJAD-KISOMI, S. MORADKHANI, and F. MOTAMEDI SADEH, “PREPARATION, BIODISTRIBUTION AND STABILITY OF [65ZN]BLEOMYCIN COMPLEX,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 12, no. 3, pp. 115–122, 2004, [Online]. Available: https://sid.ir/paper/275217/en

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