VALIDATION OF 13C-UREA BREATH TEST WITH NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION: A SURVEY IN IRANIAN POPULATION

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BEYKI D.; EFTEKHARI MEHRDAD; FARD A.; FALAHI B.; KHALAJ A.; DOULATABADI R.; AL-SEYED HOSSEIN M.H.; KHOUSHAYAND M.R.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2005 | Volume:13 | Issue:2 Page(s): 52-55

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Title

VALIDATION OF 13C-UREA BREATH TEST WITH NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION: A SURVEY IN IRANIAN POPULATION

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Keywords

H. PYLORI

13C-UREA BREATH TEST

NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY.

Abstract

The urea breath test (UBT) which is carried out with 13C or 14C labeled urea is one of the most important non invasive methods for detection of Helicobacter pylori infection. Application of 13C-UBT is becoming increasingly popular because of its non radioactive nature which makes it suitable for diagnostic purposes in children and women of child bearing ages. While isotope ratio mass spectrometer (IRMS) is generally used to detect 13C in expired breath, this instrument is expensive and recently non dispersive isotope selective infrared (NDIR) spectroscopy which is a lower cost technique has been employed as a reliable counterpart for IRMS in small clinics. The aim of this study was to assess the validity of NDIR spectroscopy technique in Iranian population in comparison with histological examination, rapid urease test and 14C-urea breath test as gold standard. Seventy six patients with dyspepsia were underwent 13C-UBT for diagnosis of Helicobacter pylori infection. Good agreements were found between the 13C-UBT and gold standard methods. The 13C-UBT showed 100% sensitivity, 97.3% specificity, 97.56% positive predictive value, 100% negative predictive value and 98.65% accuracy. On the basis of these results it could be concluded that 13C-UBT performed with NDIR spectroscopy is a reliable, accurate and non invasive diagnostic tool for detection of Helicobacter pylori infection in the Iranian population.

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APA: Copy

BEYKI, D., EFTEKHARI, MEHRDAD, FARD, A., FALAHI, B., KHALAJ, A., DOULATABADI, R., AL-SEYED HOSSEIN, M.H., & KHOUSHAYAND, M.R.. (2005). VALIDATION OF 13C-UREA BREATH TEST WITH NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION: A SURVEY IN IRANIAN POPULATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(2), 52-55. SID. https://sid.ir/paper/275243/en

Vancouver: Copy

BEYKI D., EFTEKHARI MEHRDAD, FARD A., FALAHI B., KHALAJ A., DOULATABADI R., AL-SEYED HOSSEIN M.H., KHOUSHAYAND M.R.. VALIDATION OF 13C-UREA BREATH TEST WITH NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION: A SURVEY IN IRANIAN POPULATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(2):52-55. Available from: https://sid.ir/paper/275243/en

IEEE: Copy

D. BEYKI, MEHRDAD EFTEKHARI, A. FARD, B. FALAHI, A. KHALAJ, R. DOULATABADI, M.H. AL-SEYED HOSSEIN, and M.R. KHOUSHAYAND, “VALIDATION OF 13C-UREA BREATH TEST WITH NON DISPERSIVE ISOTOPE SELECTIVE INFRARED SPECTROSCOPY FOR THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION: A SURVEY IN IRANIAN POPULATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 2, pp. 52–55, 2005, [Online]. Available: https://sid.ir/paper/275243/en

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