SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES

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FOROUMADI A.; SHEYBANI VAHID; SAKHTEMAN A.; ABASI M.; SHAFIEI A.; RAMESHK M.; FARAZIFARD R.; TABATABAI S.A.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2007 | Volume:15 | Issue:2 Page(s): 89-93

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Title

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES

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Keywords

4-THIADIAZOLE

ANTICONVULSANT ACTIVITY

MAXIMAL ELECTROSHOCK

Abstract

Several novel 2-amino-5-[4-chloro-2-(2-chlorophenoxy)phenyl]-1,3,4-THIADIAZOLE derivatives 4a-d were synthesized and their ANTICONVULSANT ACTIVITY was determined by evaluation of the ability of theses compounds to protect mice against convulsion induced by a lethal doses of pentylentetrazole (PTZ) and MAXIMAL ELECTROSHOCK (MES). The result of anticonvulsant data shows that among the synthesized compounds, 5-[4-chloro-2-(2-chlorophenoxy) phenyl]-N-ethyl-1,3,4-thiadiazol-2-amine 4c was the most active compound in both MES and PTZ tests with an ED50 of 20.11 and 35.33 mg/kg, respectively.

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APA: Copy

FOROUMADI, A., SHEYBANI, VAHID, SAKHTEMAN, A., ABASI, M., SHAFIEI, A., RAMESHK, M., FARAZIFARD, R., & TABATABAI, S.A.. (2007). SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(2), 89-93. SID. https://sid.ir/paper/275399/en

Vancouver: Copy

FOROUMADI A., SHEYBANI VAHID, SAKHTEMAN A., ABASI M., SHAFIEI A., RAMESHK M., FARAZIFARD R., TABATABAI S.A.. SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(2):89-93. Available from: https://sid.ir/paper/275399/en

IEEE: Copy

A. FOROUMADI, VAHID SHEYBANI, A. SAKHTEMAN, M. ABASI, A. SHAFIEI, M. RAMESHK, R. FARAZIFARD, and S.A. TABATABAI, “SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 2, pp. 89–93, 2007, [Online]. Available: https://sid.ir/paper/275399/en

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