IN-VITRO/IN-VIVO COMPARISON OF LEUPROLIDE ACETATE RELEASE FROM AN IN-SITU FORMING PLGA SYSTEM

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MASHAYEKHI ROYA; MOBEDI HAMID; NAJAFI JAMAL; ENAYATI MARJAN

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:7 Page(s): 0-0

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Information Journal Paper

Title

IN-VITRO/IN-VIVO COMPARISON OF LEUPROLIDE ACETATE RELEASE FROM AN IN-SITU FORMING PLGA SYSTEM

Author(s)

MASHAYEKHI ROYA | MOBEDI HAMID | NAJAFI JAMAL | ENAYATI MARJAN | Issue Writer Certificate

Keywords

DRUG DELIVERY SYSTEM

IN-VITRO

IN-VIVO

BIODEGRADABLE POLYMER

RAT

POLY (LACTIDE-CO-GLYCOLIDE) (PLGA)

Abstract

A poly (lactide-co-glycolide) (PLGA) implant was used to control the release profile of leuprolide acetate (LA) drug. The system is an in-situ polymeric precipitation system. And the formulation consisted of PLGA polymer, LA drug and N-methyl-2-pyrrolidon solvent with no additives. First, the formulation was injected into PBS solution for IN-VITRO studies and then it was administered to the animal models (female RATs) for IN-VIVO release studies. The release profiles of leuprolide acetate were measured by UV spectrophotometry for a period of 28 days. The initial burst release of LA was 14% in IN-VITRO whereas it was 7% in IN-VIVO. IN-VITRO and IN-VIVO release profiles of LA had similar trends after 72 hours. However, the RATe of LA release was slower IN-VIVO. This might be attributed to the limited diffusion process of solvent and the drug molecules. This could be due to presence of an additional pressure caused by the surrounding tissue and also the presence of small amount of water between cells in the subcutaneous site. Cross-section and surface of the implants were studied via scanning electron microscopy. Morphology of both IN-VITRO and IN-VIVO implants confirmed the release behaviours. No toxicity effects were reported in the histopathological assay. Furthermore, the pharmacological analysis showed more inactive ovaries due to release of LA.

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APA: Copy

MASHAYEKHI, ROYA, MOBEDI, HAMID, NAJAFI, JAMAL, & ENAYATI, MARJAN. (2013). IN-VITRO/IN-VIVO COMPARISON OF LEUPROLIDE ACETATE RELEASE FROM AN IN-SITU FORMING PLGA SYSTEM. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(7), 0-0. SID. https://sid.ir/paper/275647/en

Vancouver: Copy

MASHAYEKHI ROYA, MOBEDI HAMID, NAJAFI JAMAL, ENAYATI MARJAN. IN-VITRO/IN-VIVO COMPARISON OF LEUPROLIDE ACETATE RELEASE FROM AN IN-SITU FORMING PLGA SYSTEM. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(7):0-0. Available from: https://sid.ir/paper/275647/en

IEEE: Copy

ROYA MASHAYEKHI, HAMID MOBEDI, JAMAL NAJAFI, and MARJAN ENAYATI, “IN-VITRO/IN-VIVO COMPARISON OF LEUPROLIDE ACETATE RELEASE FROM AN IN-SITU FORMING PLGA SYSTEM,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 7, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275647/en

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