EFFECTS OF THE ANTI-DIABETIC AND ANTI-NEUROPATHY EFFECTS OF ONOSMA DICHROANTHUM IN AN EXPERIMENTAL MODEL OF DIABETES BY STREPTOZOCIN IN MICE

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NADERI M.; DEHPOUR A.A.; YAGHUBI BEKLAR S.; FATHI H.; ATAEE R.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2017 | Volume:19 | Issue:3 Page(s): 161-169

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Title

EFFECTS OF THE ANTI-DIABETIC AND ANTI-NEUROPATHY EFFECTS OF ONOSMA DICHROANTHUM IN AN EXPERIMENTAL MODEL OF DIABETES BY STREPTOZOCIN IN MICE

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Keywords

ONOSMA DICHROANTHUMQ1

DIABETESQ3

NEUROPATHYQ2

OXIDATIVE STRESSQ1

GSHQ2

MDAQ2

Abstract

Introduction: DIABETES is a metabolic disease with hyperglycemia, decrease in insulin secretion or de-sensitization of peripheral cells to insulin. Onosma is a species of Boraginaceae which although it is used in traditional medicine for its anti-oxidant, anti-inflammatory and antibiotic properties, data on its anti-diabetic effects are limited. This research has been designed to assess its' anti-diabetc, anti-neuropathy and anti-oxidative stress effects in an in-vivo model of DIABETES.Materials and Methods: Hydroalcoholic extract was prepared from over-ground organs, (shoots and leaves) and underground organs (roots), and administered by gavage (50 mg/kg) for 3 weeks to mice in a streptozocin induced diabetic model. After the treatment period, blood glucose, weight and NEUROPATHY were determined and for positive control, metformin (50 mg/kg) was used.After removing the brain and liver of mice and homogenization of tissues, the MDA and Glutathione contents of the tissues have been assayed by a colorimetric method.Results: Results of this research show that hydroalcoholic extract ofOnosma d. has anti-diabeti properties which have beneficial effects for some parameters such as hypoglycemia and reducing MDA, the effect of underground organs as roots extracts were better. However for increasing weight, diminishing NEUROPATHY and increasing GSH contents, the effects of over-ground organs as leaves and shoots extracts were more significant.Conclusion: Results of this research indicate the anti-diabetic and anti-neuropathy properties ofONOSMA DICHROANTHUM as a herbal medicine, related to its antioxidant abilities and limited side effects, can hence be used for treatment with other anti-diabetic drugs.

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APA: Copy

NADERI, M., DEHPOUR, A.A., YAGHUBI BEKLAR, S., FATHI, H., & ATAEE, R.. (2017). EFFECTS OF THE ANTI-DIABETIC AND ANTI-NEUROPATHY EFFECTS OF ONOSMA DICHROANTHUM IN AN EXPERIMENTAL MODEL OF DIABETES BY STREPTOZOCIN IN MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 19(3), 161-169. SID. https://sid.ir/paper/27692/en

Vancouver: Copy

NADERI M., DEHPOUR A.A., YAGHUBI BEKLAR S., FATHI H., ATAEE R.. EFFECTS OF THE ANTI-DIABETIC AND ANTI-NEUROPATHY EFFECTS OF ONOSMA DICHROANTHUM IN AN EXPERIMENTAL MODEL OF DIABETES BY STREPTOZOCIN IN MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2017;19(3):161-169. Available from: https://sid.ir/paper/27692/en

IEEE: Copy

M. NADERI, A.A. DEHPOUR, S. YAGHUBI BEKLAR, H. FATHI, and R. ATAEE, “EFFECTS OF THE ANTI-DIABETIC AND ANTI-NEUROPATHY EFFECTS OF ONOSMA DICHROANTHUM IN AN EXPERIMENTAL MODEL OF DIABETES BY STREPTOZOCIN IN MICE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 19, no. 3, pp. 161–169, 2017, [Online]. Available: https://sid.ir/paper/27692/en

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