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Information Journal Paper

Title

EFFECT OF SUBCHRONIC ADMINISTRATION OF AQUEOUS ARTEMISIA ANNUA EXTRACT ON-ADRENOCEPTOR AGONIST-INDUCED CONTRACTION OF ISOLATED AORTA IN RAT

Pages

  57-62

Abstract

 Artemisia species, growing in almost all the northern hemisphere, is used in folk medicine of some countries as a remedy for hypertension. Since some cardiovascular disorders including hypertension are accompanied with altered responsiveness of vascular alpha-adrenergic receptors, the effect of AQUEOUS ARTEMISIA ANNUA EXTRACT (100 and 200 mg kg-1) on -adrenoceptor agonist-induced contraction of RAT aorta was investigsted. After 4 weeks, the contraction and endothelium-dependent and -independent relaxation response of extract-treated RATs were recorded. The results showed that the contractile response of AORTIC RINGS with endothelium to PHENYLEPHRINE in extract-treated RATs decreases (P<0.01-0.0001) and their endothelium-dependent relaxation response to acetylcholine increases (P<0.01-0.001) significantly in comparison with controls. Endothelium-denuded AORTIC RINGS from extract-treated RATs also showed a significant decrease (P<0.05) in contractile response, but there was no considerable difference in their endothelium-independent relaxation response to isosorbide dinitrate. These data suggest that the aqueous extract of Artemisia annua could attenuate contractile response and enhance the endothelium-dependent relaxation response of AORTIC RINGS from normal rats.

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    APA: Copy

    BALUCHNEJADMOJARAD, TOURANDOKHT, ZARE, N., & ROUGHANI, M.. (2005). EFFECT OF SUBCHRONIC ADMINISTRATION OF AQUEOUS ARTEMISIA ANNUA EXTRACT ON-ADRENOCEPTOR AGONIST-INDUCED CONTRACTION OF ISOLATED AORTA IN RAT. IRANIAN BIOMEDICAL JOURNAL, 9(2), 57-62. SID. https://sid.ir/paper/277020/en

    Vancouver: Copy

    BALUCHNEJADMOJARAD TOURANDOKHT, ZARE N., ROUGHANI M.. EFFECT OF SUBCHRONIC ADMINISTRATION OF AQUEOUS ARTEMISIA ANNUA EXTRACT ON-ADRENOCEPTOR AGONIST-INDUCED CONTRACTION OF ISOLATED AORTA IN RAT. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2005;9(2):57-62. Available from: https://sid.ir/paper/277020/en

    IEEE: Copy

    TOURANDOKHT BALUCHNEJADMOJARAD, N. ZARE, and M. ROUGHANI, “EFFECT OF SUBCHRONIC ADMINISTRATION OF AQUEOUS ARTEMISIA ANNUA EXTRACT ON-ADRENOCEPTOR AGONIST-INDUCED CONTRACTION OF ISOLATED AORTA IN RAT,” IRANIAN BIOMEDICAL JOURNAL, vol. 9, no. 2, pp. 57–62, 2005, [Online]. Available: https://sid.ir/paper/277020/en

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