PROTECTIVE EFFECTS OF INTERLEUKIN-4 ON TISSUE DESTRUCTION AND MORPHOLOGICAL CHANGES OF BOVINE NASAL CHONDROCYTES IN VITRO

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YADEGARI MARYAM; ORAZIZADEH MAHMOUD; HASHEMITABAR MAHMOUD; KHODADADI ALI

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2013 | Volume:17 | Issue:4 Page(s): 187-193

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Title

PROTECTIVE EFFECTS OF INTERLEUKIN-4 ON TISSUE DESTRUCTION AND MORPHOLOGICAL CHANGES OF BOVINE NASAL CHONDROCYTES IN VITRO

Author(s)

YADEGARI MARYAM | ORAZIZADEH MAHMOUD | HASHEMITABAR MAHMOUD | KHODADADI ALI | Issue Writer Certificate

Keywords

CHONDROCYTE

INTERLEUKIN-1

INTERLEUKIN-4

MATRIX METALLOPROTEINASE-1

BOVINE NASAL CARTILAGE

Abstract

Background: Previous studies have shown that some cytokines have protective effects on cartilage in joint diseases. In the current study, effects of IL-4 against morphological changes and tissue degradation induced by IL- 1a on BOVINE NASAL CARTILAGE (BNC) explants were investigated.Methods: Fresh BNC samples were prepared from a slaughterhouse under sterile conditions. BNC explants culture was treated with both IL-la (10 ng/ml) and IL-4 (50 ng/ml) at the same time for 28 days. The morphological characteristics of explants were assessed by using histology techniques and invert microscopy. MATRIX METALLOPROTEINASE-1 (MMP-1) production was assessed within different days by using Western blotting.Results: IL-la induced prominent cartilage morphology degradation. The pro and active form of MMP-1 band substantially increased at day 21 of culture. In the presence of both IL-la and IL-4, CHONDROCYTEs preserved their ordinary normal phenotype with intact extracellular matrix. In addition, a significant reduction in pro-MMP-1 and inhibition of active MMP-1 was seen.Conclusion: In conclusion, IL-4 could be regarded as a potential candidate in cartilage protecting against the degradation changes of IL-la. It seems that the preservation effect of IL-4 is associated with significant reduction of MMP-1.

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APA: Copy

YADEGARI, MARYAM, ORAZIZADEH, MAHMOUD, HASHEMITABAR, MAHMOUD, & KHODADADI, ALI. (2013). PROTECTIVE EFFECTS OF INTERLEUKIN-4 ON TISSUE DESTRUCTION AND MORPHOLOGICAL CHANGES OF BOVINE NASAL CHONDROCYTES IN VITRO. IRANIAN BIOMEDICAL JOURNAL, 17(4), 187-193. SID. https://sid.ir/paper/277363/en

Vancouver: Copy

YADEGARI MARYAM, ORAZIZADEH MAHMOUD, HASHEMITABAR MAHMOUD, KHODADADI ALI. PROTECTIVE EFFECTS OF INTERLEUKIN-4 ON TISSUE DESTRUCTION AND MORPHOLOGICAL CHANGES OF BOVINE NASAL CHONDROCYTES IN VITRO. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2013;17(4):187-193. Available from: https://sid.ir/paper/277363/en

IEEE: Copy

MARYAM YADEGARI, MAHMOUD ORAZIZADEH, MAHMOUD HASHEMITABAR, and ALI KHODADADI, “PROTECTIVE EFFECTS OF INTERLEUKIN-4 ON TISSUE DESTRUCTION AND MORPHOLOGICAL CHANGES OF BOVINE NASAL CHONDROCYTES IN VITRO,” IRANIAN BIOMEDICAL JOURNAL, vol. 17, no. 4, pp. 187–193, 2013, [Online]. Available: https://sid.ir/paper/277363/en

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