THE EFFECT OF LONG-TERM CONSUMPTION OF COMMIPHORA MUKUL FEEDING ON THE SERUM LEVELS OF GLUCOSE AND LIPIDS OF DIABETIC RATS

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KHALILI MOHSEN; VAEZ MAHDAVI M.R.; KIASALARI Z.; ANSARI F.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2009 | Volume:11 | Issue:1 (SN 43) Page(s): 71-77

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Title

THE EFFECT OF LONG-TERM CONSUMPTION OF COMMIPHORA MUKUL FEEDING ON THE SERUM LEVELS OF GLUCOSE AND LIPIDS OF DIABETIC RATS

Author(s)

KHALILI MOHSEN | VAEZ MAHDAVI M.R. | KIASALARI Z. | ANSARI F. | Issue Writer Certificate

Keywords

COMMIPHORA MUKULQ3

GLUCOSEQ3

LIPIDQ3

DIABETES MELLITUSQ3

RATQ2

Abstract

Introduction: Considering the beneficial anti-lipidemic effects of COMMIPHORA MUKUL (CM) (ashwagandha) on metabolism, the hypoglycemic and hypolipidemic effects of this plant were investigated in an experimental model of DIABETES MELLITUS. Materials and Methods: Fifty-six male Wistar RATs were randomly divided into 4 groups, i.e. control, CM-treated control, diabetic, and CMtreated diabetic groups. The treatment groups received oral administration of plant-mixed pelleted food (6.25%) for two months. Serum GLUCOSE, triglyceride, total cholesterol, LDL- and HDLcholesterol levels were determined before the study, and at 4 and 8th weeks after the experiment. Results: The weight loss (%) in CM-treated diabetic RATs (7.8± 2.2%) compared to diabetic (29.8 ± 2.2%) ones showed a significant difference (P< 0.05). Serum GLUCOSE levels in diabetic RATs increased significantly, compared to CM-diabetic animals (0.05), and in both groups compared to controls (0.01). Triglyceride and cholesterol levels in the diabetic group increased non significantly, but in CM-treated diabetic RATs, these levels decreased more significantly. Finally, in CM-treated control and the CM-diabetic animals, mild decrease in LDL and increase in HDL, demonstrateds a suitable HDL/LDL RATio in CM-treated control (24%) and CM-diabetic RATs (248%) as compared to controls.Conclusion: Oral chronic administration of CM diminished the weight loss of animals with STZ inducted diabetes (STZ-groups) more significantly. Also, a marked hypoglycemic effect was seen in CM-treated RATs. Feeding animals with CM leads to appropriate changes in blood LIPID profiles i.e. high RATio of HDL/LDL.

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APA: Copy

KHALILI, MOHSEN, VAEZ MAHDAVI, M.R., KIASALARI, Z., & ANSARI, F.. (2009). THE EFFECT OF LONG-TERM CONSUMPTION OF COMMIPHORA MUKUL FEEDING ON THE SERUM LEVELS OF GLUCOSE AND LIPIDS OF DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 11(1 (SN 43)), 71-77. SID. https://sid.ir/paper/27812/en

Vancouver: Copy

KHALILI MOHSEN, VAEZ MAHDAVI M.R., KIASALARI Z., ANSARI F.. THE EFFECT OF LONG-TERM CONSUMPTION OF COMMIPHORA MUKUL FEEDING ON THE SERUM LEVELS OF GLUCOSE AND LIPIDS OF DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2009;11(1 (SN 43)):71-77. Available from: https://sid.ir/paper/27812/en

IEEE: Copy

MOHSEN KHALILI, M.R. VAEZ MAHDAVI, Z. KIASALARI, and F. ANSARI, “THE EFFECT OF LONG-TERM CONSUMPTION OF COMMIPHORA MUKUL FEEDING ON THE SERUM LEVELS OF GLUCOSE AND LIPIDS OF DIABETIC RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 11, no. 1 (SN 43), pp. 71–77, 2009, [Online]. Available: https://sid.ir/paper/27812/en

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