HYPOLIPIDEMIC EFFECT OF AQUEOUS LEAF EXTRACT OF TRIGONELLA FOENUM-GRAECUM IN DIABETIC RATS

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT; ROGHANI DEHLORDI F.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2005 | Volume:7 | Issue:2 (SN 26) Page(s): 167-171

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Title

HYPOLIPIDEMIC EFFECT OF AQUEOUS LEAF EXTRACT OF TRIGONELLA FOENUM-GRAECUM IN DIABETIC RATS

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | ROGHANI DEHLORDI F. | Issue Writer Certificate

Keywords

FENUGREEKQ3

DIABETES MELLITUSQ3

TRIGLYCERIDEQ3

TOTAL CHOLESTEROLQ4

LDLQ3

HDLQ3

RATQ2

Abstract

Introduction: Considering the hypoglycemic and hypolipidemic effect of the FENUGREEK seed and hypoglycemic effect of its leaf, this study was conducted to evaluate the hypolipidemic effect of its aqueous leaf extract. Materials and Methods: Male Wistar RATs were divided into control, extract-treated control, diabetic, and extract-treated diabetic groups. FENUGREEK extract was administered at doses of 100 and/or 200 mg/Kg (i.p) every other day three days after the induction of diabetes for a period of 2 months. Serum TOTAL CHOLESTEROL, TRIGLYCERIDE, LDL-and HDL-cholesterol levels were measured one week before the study and again 4 and 8 weeks after the experiment. Results: Serum TOTAL CHOLESTEROL significantly increased (p<0.05) in diabetic RATs, with the extract treatment having no effect in this respect; there was a non-significant increase in TRIGLYCERIDE levels in diabetic RATs again with no effect of extract treatment. On the other hand, LDL- and HDL cholesterol levels significantly increased (p<0.01) and decreased (p<0.05) in diabetic RATs respectively, and administration of the extract significantly (p<0.05 and p<0.01) reversed these changes. Conclusion: The results showed that treatment of diabetic RATs with aqueous extract of FENUGREEK could improve the inappropriate changes in LDL-and HDL-cholesterol and this could reduce the ensuing cardiovascular complications caused by DIABETES MELLITUS.

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APA: Copy

ROUGHANI, M., BALUCHNEJADMOJARAD, TOURANDOKHT, & ROGHANI DEHLORDI, F.. (2005). HYPOLIPIDEMIC EFFECT OF AQUEOUS LEAF EXTRACT OF TRIGONELLA FOENUM-GRAECUM IN DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(2 (SN 26)), 167-171. SID. https://sid.ir/paper/27865/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI DEHLORDI F.. HYPOLIPIDEMIC EFFECT OF AQUEOUS LEAF EXTRACT OF TRIGONELLA FOENUM-GRAECUM IN DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(2 (SN 26)):167-171. Available from: https://sid.ir/paper/27865/en

IEEE: Copy

M. ROUGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and F. ROGHANI DEHLORDI, “HYPOLIPIDEMIC EFFECT OF AQUEOUS LEAF EXTRACT OF TRIGONELLA FOENUM-GRAECUM IN DIABETIC RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. 2 (SN 26), pp. 167–171, 2005, [Online]. Available: https://sid.ir/paper/27865/en

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