CHRONIC EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES IN REGENERATION OF Β-CELLS OF HYPERGLYCEMIC STZ RATS

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KHOURI V.; GHOLALIPOUR M.J.

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Journal: Journal of Medicinal Plants Year:2006 | Volume:5 | Issue:Supplement Page(s): 36-41

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Title

CHRONIC EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES IN REGENERATION OF Β-CELLS OF HYPERGLYCEMIC STZ RATS

Author(s)

KHOURI V. | GHOLALIPOUR M.J. | Issue Writer Certificate

Keywords

HYPERGLYCEMIAQ4

URTICA DIOICAQ3

BETA CELLSQ3

DIABETICQ3

Abstract

Background: URTICA DIOICA has been used in Iranian traditional medicine as a hypoglycemic agent. However there are reports with different results about the hypoglycemic activity of URTICA DIOICA. Objective: This study was done to determine the chronic effect of URTICA DIOICA leaf extract in hyperglycemic Wistar rats. Methods: 30 Wistar rats were allocated in groups of normal, hyperglycemic and treatment. HYPERGLYCEMIA in rats was induced by streptozotocin; IP. Animals in treatment group received hydroalcholic extract of URTICA DIOICA (100 mg/kg/day) for 4 weeks intraperitoneally. The blood glucose was measured by using a Glucometer in 1st, 3rd and 5th weeks. The animals in each group were sacrificed by ether anesthesia and pancreas β - cells in three groups were counted by histological examination. Results: the Means±SE of blood glucose concentrations in DIABETIC group was significantly lower than treatment groups (253.8 ± 24.2 versa 356.2 ± 28.1 mg/dl). The percent of β-cells were 73.6%, 1.9% and 1.3% in normal, hyperglycemic and treatment groups, respectively. Conclusion: This study showed that chronic administration of hydroalcholic extract of URTICA DIOICA has no hypoglycemic effect and regeneration of β-cells of langerhans in hyperglycemic rats.

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APA: Copy

KHOURI, V., & GHOLALIPOUR, M.J.. (2006). CHRONIC EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES IN REGENERATION OF Β-CELLS OF HYPERGLYCEMIC STZ RATS. JOURNAL OF MEDICINAL PLANTS, 5(Supplement), 36-41. SID. https://sid.ir/paper/15203/en

Vancouver: Copy

KHOURI V., GHOLALIPOUR M.J.. CHRONIC EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES IN REGENERATION OF Β-CELLS OF HYPERGLYCEMIC STZ RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2006;5(Supplement):36-41. Available from: https://sid.ir/paper/15203/en

IEEE: Copy

V. KHOURI, and M.J. GHOLALIPOUR, “CHRONIC EFFECT OF THE HYDROALCHOLIC EXTRACT OF URTICA DIOICA LEAVES IN REGENERATION OF Β-CELLS OF HYPERGLYCEMIC STZ RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 5, no. Supplement, pp. 36–41, 2006, [Online]. Available: https://sid.ir/paper/15203/en

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