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Information Journal Paper

Title

PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS

Author(s)

 SOHANAKI HAMID | BALUCHNEJADMOJARAD TOURANDOKHT | NIKBAKHT FARNAZ | ROGHANI MEHRDAD | Issue Writer Certificate 

Pages

  245-250

Abstract

 ALZHEIMER’S DISEASE (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. PELARGONIDIN (Pel), an anthocyanin derivative, is an ESTROGEN RECEPTOR agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Ab) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential ESTROGEN RECEPTOR role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Ab intrahippocampal microinjected, Pel pretreated (10 mg/kg, P.O), a estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and b estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Ab were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Ab microinjections significantly improved step-through latency (P<0.001) in PASSIVE AVOIDANCE TEST. In a and b estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Ab induced MEMORY DYSFUNCTION in PASSIVE AVOIDANCE TEST performance through ESTROGEN RECEPTOR independently related pathways.

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    Cite

    APA: Copy

    SOHANAKI, HAMID, BALUCHNEJADMOJARAD, TOURANDOKHT, NIKBAKHT, FARNAZ, & ROGHANI, MEHRDAD. (2016). PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS. ACTA MEDICA IRANICA, 54(4), 245-250. SID. https://sid.ir/paper/278877/en

    Vancouver: Copy

    SOHANAKI HAMID, BALUCHNEJADMOJARAD TOURANDOKHT, NIKBAKHT FARNAZ, ROGHANI MEHRDAD. PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS. ACTA MEDICA IRANICA[Internet]. 2016;54(4):245-250. Available from: https://sid.ir/paper/278877/en

    IEEE: Copy

    HAMID SOHANAKI, TOURANDOKHT BALUCHNEJADMOJARAD, FARNAZ NIKBAKHT, and MEHRDAD ROGHANI, “PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS,” ACTA MEDICA IRANICA, vol. 54, no. 4, pp. 245–250, 2016, [Online]. Available: https://sid.ir/paper/278877/en

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