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Information Journal Paper

Title

Detection and Genotyping of Epstein-Bar Virus Among Paraffin Embedded Tissues of Hodgkin and Non-Hodgkin's Lymphoma Patients in Ahvaz, Iran

Pages

  434-440

Abstract

 Epstein-Barr virus (EBV) is a DNA virus which belongs to the Herpesviridae family, has been infected with 90% of the world’ s population. EBV is transmitted through saliva and associated with different diseases such as Infectious Mononucleosis, Nasopharyngeal Carcinoma, Burkitt`s lymphoma, Hodgkin and Non-Hodgkin`s lymphoma. This study was designed to determine the frequency of EBV DNA and genotyping of this virus in histological tissues of Hodgkin and Non-Hodgkin's lymphoma in Ahvaz, Iran. In this study, 12 samples of Hodgkin and 29 samples of Non-Hodgkin`s lymphoma were examined from Ahvaz Imam Khomeini Hospital. After deparaffinization and DNA extraction, Nested-PCR technique was carried out on Epstein-Barr nuclear antigen 1 (EBNA-1) and Epstein-Barr nuclear antigen 3C (EBNA-3C) regions in order to detect EBV genome and genotype in tumoral tissues. Among 12 cases of Hodgkin`s lymphoma, 3 (25%) cases and among 29 cases of Non-Hodgkin's lymphoma, 14 (48%) cases were positive for EBV. All 3 EBV positive cases of Hodgkin`s lymphoma and a number of 8 (57%) cases of Non-Hodgkin`s lymphoma belonged to the adolescence age group which proves an association between age and EBV positive in Hodgkin and Non-Hodgkin`s lymphoma according to Fisher`s exact test (P=0. 03). All EBV positive cases in Hodgkin and Non-Hodgkin`s lymphoma were EBV-1. The results of this study revealed that EBV played a possible important role in Hodgkin and Non-Hodgkin`s lymphoma especially in adults. Also, the main genotype of virus in the current study was EBV-1.

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    APA: Copy

    HABIBIAN, ALA, MAKVANDI, MANOOCHEHR, SAMARBAF ZADEH, ALIREZA, NEISI, NILOOFAR, SOLEIMANI JELODAR, RAHIM, MAKVANDI, KAMYAR, & Izadi, Shima. (2018). Detection and Genotyping of Epstein-Bar Virus Among Paraffin Embedded Tissues of Hodgkin and Non-Hodgkin's Lymphoma Patients in Ahvaz, Iran. ACTA MEDICA IRANICA, 56(7), 434-440. SID. https://sid.ir/paper/278993/en

    Vancouver: Copy

    HABIBIAN ALA, MAKVANDI MANOOCHEHR, SAMARBAF ZADEH ALIREZA, NEISI NILOOFAR, SOLEIMANI JELODAR RAHIM, MAKVANDI KAMYAR, Izadi Shima. Detection and Genotyping of Epstein-Bar Virus Among Paraffin Embedded Tissues of Hodgkin and Non-Hodgkin's Lymphoma Patients in Ahvaz, Iran. ACTA MEDICA IRANICA[Internet]. 2018;56(7):434-440. Available from: https://sid.ir/paper/278993/en

    IEEE: Copy

    ALA HABIBIAN, MANOOCHEHR MAKVANDI, ALIREZA SAMARBAF ZADEH, NILOOFAR NEISI, RAHIM SOLEIMANI JELODAR, KAMYAR MAKVANDI, and Shima Izadi, “Detection and Genotyping of Epstein-Bar Virus Among Paraffin Embedded Tissues of Hodgkin and Non-Hodgkin's Lymphoma Patients in Ahvaz, Iran,” ACTA MEDICA IRANICA, vol. 56, no. 7, pp. 434–440, 2018, [Online]. Available: https://sid.ir/paper/278993/en

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