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Information Journal Paper

Title

ANTICONVULSANT EFFECTS OF CORIANDRUM SATIVUM L. SEED EXTRACTS IN MICE

Pages

  81-84

Abstract

 Background-Coriander (vernacular Geshniz) seeds have been traditionally used in Iranian medicine for their carminative, diuretic and anticonvulsant effects.Objective-The anticonvulsant effects of the aqueous and ethanolic extracts of CORIANDRUM SATIVUM seeds were studied in mice in order to evaluate the folkloric use of this plant. Methods-Two anticonvulsant evaluation tests, namely the pentylenetetrazole (PTZ) and the maximal electroshock tests, were used for assessing antiseizure effects.Results-In the PENTYLENETETRAZOLE TEST, the aqueous and ethanolic extracts prolonged the onset of clonic convulsions and the ANTICONVULSANT ACTIVITY of high dose extracts (5 mg/kg) were similar to that of phenobarbital at a dose of 20 mg/kg in the PTZ test. Both extracts in high doses decreased the duration of tonic seizures and showed a statistically significant ANTICONVULSANT ACTIVITY in the maximal electroshock test.Conclusion-Results indicate that the aqueous and ethanolic extracts of C. sativum seeds may have a beneficial effect in petit mal and grand mal seizures.

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    • Cite

    APA: Copy

    HOSSEINZADEH, H., & MADANIFARD, M.. (2000). ANTICONVULSANT EFFECTS OF CORIANDRUM SATIVUM L. SEED EXTRACTS IN MICE. ARCHIVES OF IRANIAN MEDICINE, 3(4), 81-84. SID. https://sid.ir/paper/280009/en

    Vancouver: Copy

    HOSSEINZADEH H., MADANIFARD M.. ANTICONVULSANT EFFECTS OF CORIANDRUM SATIVUM L. SEED EXTRACTS IN MICE. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2000;3(4):81-84. Available from: https://sid.ir/paper/280009/en

    IEEE: Copy

    H. HOSSEINZADEH, and M. MADANIFARD, “ANTICONVULSANT EFFECTS OF CORIANDRUM SATIVUM L. SEED EXTRACTS IN MICE,” ARCHIVES OF IRANIAN MEDICINE, vol. 3, no. 4, pp. 81–84, 2000, [Online]. Available: https://sid.ir/paper/280009/en

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