All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus

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Raee Mohammad Reza; AGHAJANI NARGESI ARASH; HEIDARI BEHNAM; MANSOURNIA MOHAMMAD ALI; LARRY MEHRDAD; Rabizadeh Soghra; Zarifkar Mitra; ESTEGHAMATI ALIREZA; NAKHJAVANI MANOUCHEHR

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2017 | Volume:20 | Issue:3 Page(s): 141-146

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Title

All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus

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Keywords

Cardiovascular diseases

diabetes mellitus

glyburide

metformin

mortality

Abstract

BACKGROUND: Both metformin and sulfonylurea (SU) drugs are among the most widely-used anti-hyperglycemic medications in patients with type 2 diabetes mellitus (T2DM). Previous studies have shown that treatment with SUs might be associated with decreased survival compared with metformin. This study aimed to evaluate all-cause and cardiovascular mortality rates between glyburide and metformin in patients diagnosed with T2DM. METHODS: This was a cohort study on 717 patients with T2DM (271 undergoing monotherapy with glyburide and 446 with metformin). Data were gathered from 2001 to 2014. All-cause and cardiovascular mortality were end-points. RESULTS: During the follow-up, 24 deaths were identified, of which 13 were cardiovascular in nature. The group with glyburide monotherapy had greater all-cause mortality (17 (6. 3%) in glyburide vs. 7 (1. 6%) in metformin, P = 0. 001) and cardiovascular mortality (11 (4. 1%) in glyburide vs. 2 (0. 4%) in metformin; P = 0. 001). metformin was more protective than glyburide for both all-cause (HR: 0. 27 [0. 10 – 0. 73] P-value = 0. 01) and cardiovascular mortality (HR: 0. 12 [0. 20 – 0. 66], P-value = 0. 01) after multiple adjustments for cardiovascular risk factors. Among adverse cardiovascular events, non-fatal MI was higher in glyburide compared to metformin monotherapy group (3. 2% vs. 0. 8%; P-value = 0. 03), but not coronary artery bypass grafting (P-value = 0. 85), stenting (P-value = 0. 69), need for angiography (P-value = 0. 24), CCU admission (P-value = 0. 34) or cerebrovascular accident (P-value = 0. 10). CONCLUSION: Treatment with glyburide is associated with increased all-cause and cardiovascular mortality in patients with T2DM.

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APA: Copy

Raee, Mohammad Reza, AGHAJANI NARGESI, ARASH, HEIDARI, BEHNAM, MANSOURNIA, MOHAMMAD ALI, LARRY, MEHRDAD, Rabizadeh, Soghra, Zarifkar, Mitra, ESTEGHAMATI, ALIREZA, & NAKHJAVANI, MANOUCHEHR. (2017). All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus. ARCHIVES OF IRANIAN MEDICINE, 20(3), 141-146. SID. https://sid.ir/paper/281479/en

Vancouver: Copy

Raee Mohammad Reza, AGHAJANI NARGESI ARASH, HEIDARI BEHNAM, MANSOURNIA MOHAMMAD ALI, LARRY MEHRDAD, Rabizadeh Soghra, Zarifkar Mitra, ESTEGHAMATI ALIREZA, NAKHJAVANI MANOUCHEHR. All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2017;20(3):141-146. Available from: https://sid.ir/paper/281479/en

IEEE: Copy

Mohammad Reza Raee, ARASH AGHAJANI NARGESI, BEHNAM HEIDARI, MOHAMMAD ALI MANSOURNIA, MEHRDAD LARRY, Soghra Rabizadeh, Mitra Zarifkar, ALIREZA ESTEGHAMATI, and MANOUCHEHR NAKHJAVANI, “All-Cause and Cardiovascular Mortality following Treatment with Metformin or Glyburide in Patients with Type 2 Diabetes Mellitus,” ARCHIVES OF IRANIAN MEDICINE, vol. 20, no. 3, pp. 141–146, 2017, [Online]. Available: https://sid.ir/paper/281479/en

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