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Information Journal Paper

Title

ANTI-PLASMODIAL ASSESSMENT OF FOUR DIFFERENTIRANIAN PROPOLIS EXTRACTS

Pages

  270-281

Abstract

 BACKGROUND: Eradication of MALARIA will depend on discovery of new intervention tools such as anti-malarial drugs. Due to the increasing interest in the application of PROPOLIS against significant clinical pathogenic agents, the aim of the present investigation was to evaluate the anti-plasmodial effect of IRANian PROPOLIS extracts against chloroquine (CQ)-sensitive Plasmodium falciparum 3D7 and Plasmodium berghei (ANKA strain). METHODS: Crude samples of honeybee (Apis mellifera) PROPOLIS were collected from four provinces in northern (Kalaleh, Golestan), northeastern (Chenaran, Razavi Khorasan), central (Taleghan, Alborz) and western (Morad Beyg, Hamedan) areas of IRAN with different types of flora. The dried PROPOLIS samples were extracted with three different solvents, including ethanol 70% (EtOH), ethyl acetate (EA) and dichloromethane (DCM). RESULTS: All extracts were shown to have in vitro ANTI-PLASMODIAL ACTIVITY with IC50 ranging from 16. 263 to 80. 012 µ g/mL using parasite lactate dehydrogenase (pLDH) assay. The DCM extract of Morad Beyg PROPOLIS indicated the highest ANTI-PLASMODIAL ACTIVITY (IC50: 16. 263 ± 2. 910 μ g/mL; P = 0. 027, Kruskal-Wallis H test). The samples were also evaluated in mice for their in vivo anti-plasmodial effect. The curative effect against established infection (Rane test) showed that both extracts at all doses (50, 100, and 200 mg/kgBW) produced ANTI-PLASMODIAL ACTIVITY against the parasite. Furthermore, using gas chromatography-mass spectrometry (GC-MS), the quantity of flavonoids in DCM and EtOH 70% extracts were found to be 7. 42% and 3. 10%, respectively. CONCLUSION: The potent ANTI-PLASMODIAL ACTIVITY of both EtOH 70% and DCM extracts of the PROPOLIS of Morad Beyg, Hamedan suggests further analyses of individual components to assess its utilization as anti-malarial drugs.

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    APA: Copy

    AFROUZAN, HOUSHANG, ZAKERI, SEDIGHEH, ABOUIE MEHRIZI, AKRAM, MOLASALEHI, SARA, TAHGHIGHI, AZAR, SHOKRGOZAR, MOHAMAD ALI, ESHAGHI, Ali, & DINPARAST DJADID, NAVID. (2017). ANTI-PLASMODIAL ASSESSMENT OF FOUR DIFFERENTIRANIAN PROPOLIS EXTRACTS. ARCHIVES OF IRANIAN MEDICINE, 20(5), 270-281. SID. https://sid.ir/paper/281636/en

    Vancouver: Copy

    AFROUZAN HOUSHANG, ZAKERI SEDIGHEH, ABOUIE MEHRIZI AKRAM, MOLASALEHI SARA, TAHGHIGHI AZAR, SHOKRGOZAR MOHAMAD ALI, ESHAGHI Ali, DINPARAST DJADID NAVID. ANTI-PLASMODIAL ASSESSMENT OF FOUR DIFFERENTIRANIAN PROPOLIS EXTRACTS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2017;20(5):270-281. Available from: https://sid.ir/paper/281636/en

    IEEE: Copy

    HOUSHANG AFROUZAN, SEDIGHEH ZAKERI, AKRAM ABOUIE MEHRIZI, SARA MOLASALEHI, AZAR TAHGHIGHI, MOHAMAD ALI SHOKRGOZAR, Ali ESHAGHI, and NAVID DINPARAST DJADID, “ANTI-PLASMODIAL ASSESSMENT OF FOUR DIFFERENTIRANIAN PROPOLIS EXTRACTS,” ARCHIVES OF IRANIAN MEDICINE, vol. 20, no. 5, pp. 270–281, 2017, [Online]. Available: https://sid.ir/paper/281636/en

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