THE PROTECTIVE EFFECTS OF MELATONIN ON THE HISTOLOGICAL CHANGES OF TESTIS IN BUSULFAN-TREATED ADULT MICE

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GHASEMIPOUR MOHAMMAD REZA; FAGHANI M.; KHAJEH JAHROMI S.

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Journal: Journal of Reproduction & Infertility Year:2010 | Volume:11 | Issue:2 (43) Page(s): 67-76

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Title

THE PROTECTIVE EFFECTS OF MELATONIN ON THE HISTOLOGICAL CHANGES OF TESTIS IN BUSULFAN-TREATED ADULT MICE

Author(s)

GHASEMIPOUR MOHAMMAD REZA | FAGHANI M. | KHAJEH JAHROMI S. | Issue Writer Certificate

Keywords

ANTINEOPLASTIC CHEMOTHERAPYQ2

BUSULFANQ2

MALE INFERTILITYQ2

MELATONINQ1

SPERMATOGENESISQ1

TESTISQ1

Abstract

Introduction: ANTINEOPLASTIC CHEMOTHERAPY is usually accompanied by fertility im-pairment and the aim of this study was to investigate the possible protective effects of MELATONIN, a pineal gland hormone with potent antioxidant activity, on BUSULFAN-treated adult male mice. Materials and Methods: This study was performed on 32, eight-week old adult male mice. The animals were divided into four groups consisting of a control and three experimental groups. The animals in the control group received dimethyl sulfoxide (DMSO), a solvent, the second group a single dose of intraperitoneal BUSULFAN (20 mg/kg), the third group a single dose of intraperitoneal MELATONIN (10 mg/kg) for five days and the fourth group MELATONIN (10 mg/kg) for five days upon an initial dose of BUSULFAN (20 mg/kg). Thirty-five days after the treatments, all the animals were sacri-ficed and dissected. Johnson's score were determined by examining the morphometric characteristics of seminiferous tubules and estimating Leydig cell volumes and germ cell counts.Results: BUSULFAN-treated mice showed reductions in Johnson's score and quality of SPERMATOGENESIS (p<0.001) in comparison to the controls. The quantitative values of seminiferous tubules (p<0.05) and the nuclear volume of Leydig cells (p<0.05) were significantly lower in the BUSULFAN-treated mice relative to the controls. In the fourth group, MELATONIN not only caused a remarkable normalization in seminiferous tubule indices (p<0.05), but also increased the nuclear volume of Leydig cells (p<0.001), the relevant Johnson's score (p<0.001) and all germ cells in comparison to the second group (p<0.05). Conclusion: MELATONIN might have a possible protective effect against BUSULFAN-induced testicular damage. Although the protective mechanism of MELATONIN has not been fully revealed, the protection seems to be through a decrease in oxidative stress.

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APA: Copy

GHASEMIPOUR, MOHAMMAD REZA, FAGHANI, M., & KHAJEH JAHROMI, S.. (2010). THE PROTECTIVE EFFECTS OF MELATONIN ON THE HISTOLOGICAL CHANGES OF TESTIS IN BUSULFAN-TREATED ADULT MICE. JOURNAL OF REPRODUCTION AND INFERTILITY, 11(2 (43)), 67-76. SID. https://sid.ir/paper/28530/en

Vancouver: Copy

GHASEMIPOUR MOHAMMAD REZA, FAGHANI M., KHAJEH JAHROMI S.. THE PROTECTIVE EFFECTS OF MELATONIN ON THE HISTOLOGICAL CHANGES OF TESTIS IN BUSULFAN-TREATED ADULT MICE. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2010;11(2 (43)):67-76. Available from: https://sid.ir/paper/28530/en

IEEE: Copy

MOHAMMAD REZA GHASEMIPOUR, M. FAGHANI, and S. KHAJEH JAHROMI, “THE PROTECTIVE EFFECTS OF MELATONIN ON THE HISTOLOGICAL CHANGES OF TESTIS IN BUSULFAN-TREATED ADULT MICE,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 11, no. 2 (43), pp. 67–76, 2010, [Online]. Available: https://sid.ir/paper/28530/en

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