BUSERELIN INHIBITS APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN IN MOUSE TESTIS

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MOHAMMAD GHASEMI F.; BAHADORI M.H.; FAGHANI M.; NASIRI E.; SOLEYMANIRAD J.

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Journal: Anatomical Sciences Journal Year:2009 | Volume:7 | Issue:27 Page(s): 45-54

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Title

BUSERELIN INHIBITS APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN IN MOUSE TESTIS

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Keywords

TESTISQ3

SPERMATOGENESISQ2

APOPTOSISQ2

BUSERELINQ3

Abstract

Purpose: The aim of this study was to investigate the effect of BUSERELIN on APOPTOSIS of male germ cells induced by busulfan in adult male mice.Materials and Methods: Male adult NMRI mice were divided into four group of eight each. Group 1 (control) administered PBS for 21 days subcutaneously, group 2 given 0.4 mg BUSERELIN for 21 days subcutaneously, group 3 given single dose of 30 mg/kg busulfan intraperitoneally and group 4 given both busulfan and BUSERELIN for 21 days. The animals were sacrificed and their testes were dissected 35 days after the treatment. Evaluations were made by determining Johnson's score and APOPTOSIS were assayed by terminal- deoxynucleotidyl- transferase-mediated dutp nick end labeling (TUNEL). Statistical analyses were performed using ANOVA test.Results: Recovery status and Johnson's score in group 4were significantly higher than those of busulfan treated group 7.71±0.69 VS 4.46±0.56 (p< 0.001). Apoptotic cells number cells were significantly more numerous in busulfan treated group than those of control 23.28±7.10 VS 3.54±1.02 (p<0.001). While BUSERELIN substantially reduced germ cell APOPTOSIS in fourth group 10.50±2.91 in comparison with third group 23.28±7.10, (p<0.001).Conclusion: Administration of BUSERELIN after testicular damage by busulfan enhances the regeneration of SPERMATOGENESIS in mouse through inhibition of APOPTOSIS in germ cells.

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References

AN ULTRASTRUCTURAL STUDY ON THE APOPTOTIC FEATURES OF SPERMATOGENIC CELLS FOLLOWING BUSULFAN TREATMENT IN ADULT MICE

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APA: Copy

MOHAMMAD GHASEMI, F., BAHADORI, M.H., FAGHANI, M., NASIRI, E., & SOLEYMANIRAD, J.. (2009). BUSERELIN INHIBITS APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN IN MOUSE TESTIS. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 7(27), 45-54. SID. https://sid.ir/paper/81547/en

Vancouver: Copy

MOHAMMAD GHASEMI F., BAHADORI M.H., FAGHANI M., NASIRI E., SOLEYMANIRAD J.. BUSERELIN INHIBITS APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN IN MOUSE TESTIS. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2009;7(27):45-54. Available from: https://sid.ir/paper/81547/en

IEEE: Copy

F. MOHAMMAD GHASEMI, M.H. BAHADORI, M. FAGHANI, E. NASIRI, and J. SOLEYMANIRAD, “BUSERELIN INHIBITS APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN IN MOUSE TESTIS,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 7, no. 27, pp. 45–54, 2009, [Online]. Available: https://sid.ir/paper/81547/en

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