THE EFFECT OF PENTOXIFYTLINE ON MOTILITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND TESTICULAR SAMPLES OF INFERTILE MEN

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KHALILI M.; VAHIDI S.A.D.; SOFLAI N.; HAIDARI A.M.

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Journal: Journal of Reproduction & Infertility Year:2000 | Volume:1 | Issue:3 (3) Page(s): 30-36

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Title

THE EFFECT OF PENTOXIFYTLINE ON MOTILITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND TESTICULAR SAMPLES OF INFERTILE MEN

Author(s)

KHALILI M. | VAHIDI S.A.D. | SOFLAI N. | HAIDARI A.M. | Issue Writer Certificate

Keywords

INFERTILE MENQ4

PENTOXIFYLLINEQ4

MOTILITYQ4

MORPHOLOGYQ4

Abstract

There are generally three factors involved in male infertility: low count, weak MOTILITY, and abnormal MORPHOLOGY of spermatozoa. Currently, it is impossible to improve the quality of sperm count and MORPHOLOGY in vitro. However, it may become possible to improve the sperm MOTILITY with the application of MOTILITY enhancer medicine. The objective of this study was to evaluate the effect of PENTOXIFYLLINE (PX) on sperm MOTILITY and MORPHOLOGY of asthenozoospermic epididymal and testicular samples. The specimen's a sperm extraction (TESE) from men with obstructive azoospermia. A total of 40 PESA and 40 TESE samples were allocated to this prospective study. Following preliminary evaluation, each sample was processed with swim up procedure and then divided into two aliquots of control (non – PX) and PX (3.5 mM PX). Following 45 min of incubation at 37°C, the percentages of MOTILITY and normal MORPHOLOGY of spermatozoa were evaluated using Meckler chamber and papaniclau staining technique, respectively. The mean sperm counts in the PESA and TESE groups were 7.4±7.3×106 and 2.43±1.3×106, respectively. The percentages of normal MORPHOLOGY in the above groups were 22.67±11.6 and 14.9±9.2 which were respectively changed to 23.2±15.7 and 9.5±1.9 with PX incubation. In addition, the percentage of control progressive MOTILITY in the PESA and TESE samples were 13.9±4.2% and 0.26±0.6% which were increased to 20.1±9.7% (p<0.001) and 0.95±0.03% (p<0.05). These results strongly suggest that PX was successful in enhancing sperm MOTILITY particularly in the PESA group. It also did not have any significant side effect on sperm MORPHOLOGY. PX is considered to be safe and cheap, with easy application which may be used for improving the male infertility treatment program. With its dual role as MOTILITY enhancer and vitality detector of spermatozoa, it can be used safely for the ICSI treatment of severe cases of asthenozoospermia.

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APA: Copy

KHALILI, M., VAHIDI, S.A.D., SOFLAI, N., & HAIDARI, A.M.. (2000). THE EFFECT OF PENTOXIFYTLINE ON MOTILITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND TESTICULAR SAMPLES OF INFERTILE MEN. JOURNAL OF REPRODUCTION AND INFERTILITY, 1(3 (3)), 30-36. SID. https://sid.ir/paper/28619/en

Vancouver: Copy

KHALILI M., VAHIDI S.A.D., SOFLAI N., HAIDARI A.M.. THE EFFECT OF PENTOXIFYTLINE ON MOTILITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND TESTICULAR SAMPLES OF INFERTILE MEN. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2000;1(3 (3)):30-36. Available from: https://sid.ir/paper/28619/en

IEEE: Copy

M. KHALILI, S.A.D. VAHIDI, N. SOFLAI, and A.M. HAIDARI, “THE EFFECT OF PENTOXIFYTLINE ON MOTILITY AND MORPHOLOGY OF SPERMATOZOA FROM EPIDIDYMAL AND TESTICULAR SAMPLES OF INFERTILE MEN,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 1, no. 3 (3), pp. 30–36, 2000, [Online]. Available: https://sid.ir/paper/28619/en

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