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Information Journal Paper

Title

Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells

Pages

  229-239

Abstract

 Background: Querce n has been reported to modulate cell prolifera on and apoptosis. The present study aimed at iden fying whether treatment of ionizing radia on (IR) combined with querce n induces apoptosis in HepG2 cells. Materials and Methods: HepG2 cells were plated at an appropriate density according to each experimental scale and irradiated with 1, 5 and 10 Gy gamma-rays from a 60Co source at room temperature. Cell viability, SOD and CAT were assessed by using commercial assay kits. Western blot analyses were done on apoptosis related proteins. The cells were treated with various concentra ons of querce n alone or in combina on with IR. Results: The cell viability was decreased in a concentra on-dependent manner 24 h a3er treatment of querce n. It was significantly lowered a3er the combined treatment of querce n with IR than that of the cells treated with querce n alone. Moreover, querce n increased the expression of p53 levels in a dosedependent manner. Combined treatment of querce n with IR significantly increased the levels of pro-apopto c proteins, cleaved caspase-3 and caspase-7, and Bax. Cell cycle analyses indicated a dras c increase in the Sub G1 popula on a3er querce n treatment combined with IR. The ac vity of caspase-3 increased coincidently with apoptosis. The combined treatment of querce n with IR decreased catalase and superoxide dismutase ac vi es, as well. Conclusion: Querce n made the radio-resistant HepG2 cells undergo apoptosis by ac va ng p53. These results suggest that the combined treatment of querce n with IR may provide an effec ve therapeu c strategy to improve the radiotherapy efficacy.

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    APA: Copy

    Jang, J.Y., Kang, M.Y., Lim, Y.K., KIM, J.H., & KIM, J.K.. (2017). Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(3), 229-239. SID. https://sid.ir/paper/286878/en

    Vancouver: Copy

    Jang J.Y., Kang M.Y., Lim Y.K., KIM J.H., KIM J.K.. Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(3):229-239. Available from: https://sid.ir/paper/286878/en

    IEEE: Copy

    J.Y. Jang, M.Y. Kang, Y.K. Lim, J.H. KIM, and J.K. KIM, “Effects of quercetin on ionizing radiation-induced cellular responses in HepG2 cells,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 3, pp. 229–239, 2017, [Online]. Available: https://sid.ir/paper/286878/en

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