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Information Journal Paper

Title

Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy

Pages

  325-341

Abstract

 About 10% of apparently normal individuals are sensi ve to clastogenic effects of physico-chemical agents. More than 45% of breast cancer pa ents’ exhibit elevated radiosensi vity. Although the nature of inherent radiosensi vity is not fully understood, but insufficiency and impaired DNA repair mechanism might be prime cause of radiosensi vity. This is evident from gene cally affected individuals such as ataxia telangiectasia, severe combined immunodeficiency, Xeroderma pigmentasum, Fanconi anemia who show sensi vity to ionizing radia on, ultraviolet light and alkyla ng agents. All these gene c diseases are caused due to impaired DNA damage repair mechanism. Radia on therapy (RT) is a common and effec ve way of treatment in several types of malignant tumors. Some cancer pa ents suffer from side effects of RT such as radia on induced early or late adverse responses in normal  ssues within weeks, months, or even years post irradia on, due to intrinsic radiosensi vity. The RT efficiency limita on raises from ionizing radia on toxicity reac ons in normal  ssues. An appropriate protocol to prevent or treat these side effects, has not been developed yet. Molecular pathways involved in adverse responses to cancer treatment agents have not been well defined. Iden fica on of molecular mechanisms may be promising to enhance the output of treatment technologies and overall survival of cancer pa ents. Several techniques such as microarray technology has been used to clarify molecular mechanisms involved in radiosensi vity by finding genes related to RT normal  ssue responses. DNA repair, apoptosis, cell cycle, and growth factor associated genes are the most important candidates in this field.

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    • Cite

    APA: Copy

    MOZDARANI, H., SALIMI, M., & Bakhtari, N.. (2017). Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(4), 325-341. SID. https://sid.ir/paper/286892/en

    Vancouver: Copy

    MOZDARANI H., SALIMI M., Bakhtari N.. Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(4):325-341. Available from: https://sid.ir/paper/286892/en

    IEEE: Copy

    H. MOZDARANI, M. SALIMI, and N. Bakhtari, “Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 4, pp. 325–341, 2017, [Online]. Available: https://sid.ir/paper/286892/en

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