DEVELOPMENTAL EXPRESSION OF TYROSINE KINASE B IN RAT VESTIBULAR NUCLEAR NEURONS RESPONDING TO HORIZONTAL AND VERTICAL LINEAR ACCELERATIONS

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LAI C.H.; LAI S.K.; ZHANG F.X.; CHAN Y.S.

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Journal: Iranian Journal of Pharmaceutical Research Year:2004 | Volume:3 | Issue:Supplement 1 Page(s): 26-26

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Title

DEVELOPMENTAL EXPRESSION OF TYROSINE KINASE B IN RAT VESTIBULAR NUCLEAR NEURONS RESPONDING TO HORIZONTAL AND VERTICAL LINEAR ACCELERATIONS

Author(s)

LAI C.H. | LAI S.K. | ZHANG F.X. | CHAN Y.S.

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Abstract

Brain-derived neurotrophic factor (BDNF) is known to be crucial for the development of peripheral vestibular neurons. However, the maturation profile of the BDNF signal transducing receptor, tyrosine kinase B (TrkB) in functionally activated otolith-related vestibular nuclear neurons of postnatal rats remains unexplored. In the present study, conscious Sprague-Dawley rats (P4 to adult) were subjected to sinusoidal linear acceleration along the vertical or horizontal axis. Neuronal activation in response to otolith stimulation was defined by the expression of c-Fos in the vestibular nucleus. Labyrinthectomized controls and normal controls showed only a few sporadically scattered c-fos-expressing neurons. In P4-6 test rats, no Fos-labeled neurons were found in the vestibular nuclei and immunostaining for TrkB was weak. The intensity for TrkB in vestibular nuclear neurons increased with age. From P7 onwards, Fos/TrkB double-labeled neurons responsive to vertical stimulation or horizontal interaural stimulation were detected; from P9 those to horizontal antero-posterior stimulation were also detected. These findings indicate a temporal disparity in the processing of gravity-related spatial orientations in space during development of central otolith neurons. At P9, Fos/TrkB double-labeled neurons responsive to horizontal interaural stimulation or vertical stimulation greatly outnumber those responsive to antero-posterior stimulation. The number of double-labeled neurons increased with age, reaching 80–85% of the total Fos-labeled vestibular nuclear neurons in the adult. Our results suggest that TrkB contributes to the mechanism of maturation in central otolith neurons.

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APA: Copy

LAI, C.H., LAI, S.K., ZHANG, F.X., & CHAN, Y.S.. (2004). DEVELOPMENTAL EXPRESSION OF TYROSINE KINASE B IN RAT VESTIBULAR NUCLEAR NEURONS RESPONDING TO HORIZONTAL AND VERTICAL LINEAR ACCELERATIONS . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 3(Supplement 1), 26-26. SID. https://sid.ir/paper/287169/en

Vancouver: Copy

LAI C.H., LAI S.K., ZHANG F.X., CHAN Y.S.. DEVELOPMENTAL EXPRESSION OF TYROSINE KINASE B IN RAT VESTIBULAR NUCLEAR NEURONS RESPONDING TO HORIZONTAL AND VERTICAL LINEAR ACCELERATIONS . IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2004;3(Supplement 1):26-26. Available from: https://sid.ir/paper/287169/en

IEEE: Copy

C.H. LAI, S.K. LAI, F.X. ZHANG, and Y.S. CHAN, “DEVELOPMENTAL EXPRESSION OF TYROSINE KINASE B IN RAT VESTIBULAR NUCLEAR NEURONS RESPONDING TO HORIZONTAL AND VERTICAL LINEAR ACCELERATIONS ,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 3, no. Supplement 1, pp. 26–26, 2004, [Online]. Available: https://sid.ir/paper/287169/en

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