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Information Journal Paper

Title

ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN IRANIAN TUBERCULOSIS PATIENTS: ROLE OF ISONIAZID METABOLIC POLYMORPHISM

Pages

  633-639

Abstract

 The aim of this study was to determine the association of n-acetyltransferase-2 POLYMORPHISMs and anti-tuberculosis drug-induced HEPATOTOXICITY in Iranian pulmonary TUBERCULOSIS patients. Acetylating phenotypes was studied in 50 Iranian pulmonary TUBERCULOSIS patients using metabolic ratio of plasma acetyl-Isoniazid to ISONIAZID. The association between HEPATOTOXICITY and the n-acetyltransferase-2 phenotype was evaluated by using the chi-square (x2) test.The metabolic ratio had a bimodal distribution with an antimode value of 1.0. Based on the metabolic ratio of the mentioned patients, 20 (40%) were slow acetylators and 30 (60%) were fast ones. HEPATOTOXICITY was manifested in 9 of 20 slow acetylators (45%) and only in 5 of 30 rapid acetylators (16.7%). There was a significant difference in the frequency of HEPATOTOXICITY between the slow and fast acetylators (x2=4.778, and p=0.03). Sex and age were not found to be risk factors for HEPATOTOXICITY. Our findings show that slow acetylation profile is significantly associated with a higher risk of developing HEPATOTOXICITY due to the anti-TB drugs in Iranian pulmonary TUBERCULOSIS patients.

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    APA: Copy

    SISTANIZAD, MOHAMMAD, AZIZI, EBRAHIM, KHALILI, HOSEIN, HAJIABDOLBAGHI, MAHBOOBEH, GHOLAMI, KHEIROLLAH, & MAHJUB, REZA. (2011). ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN IRANIAN TUBERCULOSIS PATIENTS: ROLE OF ISONIAZID METABOLIC POLYMORPHISM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 633-639. SID. https://sid.ir/paper/287854/en

    Vancouver: Copy

    SISTANIZAD MOHAMMAD, AZIZI EBRAHIM, KHALILI HOSEIN, HAJIABDOLBAGHI MAHBOOBEH, GHOLAMI KHEIROLLAH, MAHJUB REZA. ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN IRANIAN TUBERCULOSIS PATIENTS: ROLE OF ISONIAZID METABOLIC POLYMORPHISM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):633-639. Available from: https://sid.ir/paper/287854/en

    IEEE: Copy

    MOHAMMAD SISTANIZAD, EBRAHIM AZIZI, HOSEIN KHALILI, MAHBOOBEH HAJIABDOLBAGHI, KHEIROLLAH GHOLAMI, and REZA MAHJUB, “ANTITUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN IRANIAN TUBERCULOSIS PATIENTS: ROLE OF ISONIAZID METABOLIC POLYMORPHISM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 633–639, 2011, [Online]. Available: https://sid.ir/paper/287854/en

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