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Information Journal Paper

Title

POTENTIATING EFFECTS OF LACTUCA SATIVA ON PENTOBARBITAL-INDUCED SLEEP

Pages

  401-406

Abstract

 Traditionally, LACTUCA SATIVA (lettuce) has been recommended for its hypnotic property. The present study was planned to investigate SLEEP-prolonging effect of this plant. The hydro-alcoholic extract (HAE) of lettuce and its water fraction (WF), ethyl acetate fraction (EAF), and n-butanol fraction (NBF) were administrated (IP) to MICE 30 min before the PENTOBARBITAL injection. Moreover, both in-vivo and in-vitro toxicity of the extracts were determined. The quality of HAE and NBF was also evaluated using HPLC fingerprint. The HAE prolonged the PENTOBARBITAL-induced SLEEP duration at dose of 400 mg/Kg. The NBF was the only fraction which could increase the SLEEP duration and decrease SLEEP latency. The effects of NBF were comparable to those of induced by diazepam. The LD50-value for HAE was found to be 4.8 g/Kg. No neurotoxic effect was observed either by HAE or by its fractions in cultured PC12 neuron-like cells. The results suggest that lettuce potentiates PENTOBARBITAL hypnosis without major toxic effect. The main component (s) responsible for this effect is most likely to be non-polar agent (s) which found in NBF of this plant.

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    APA: Copy

    GHORBANI, AHMAD, RAKHSHANDEH, HASSAN, & SADEGHNIA, HAMID REZA. (2013). POTENTIATING EFFECTS OF LACTUCA SATIVA ON PENTOBARBITAL-INDUCED SLEEP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 401-406. SID. https://sid.ir/paper/288166/en

    Vancouver: Copy

    GHORBANI AHMAD, RAKHSHANDEH HASSAN, SADEGHNIA HAMID REZA. POTENTIATING EFFECTS OF LACTUCA SATIVA ON PENTOBARBITAL-INDUCED SLEEP. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):401-406. Available from: https://sid.ir/paper/288166/en

    IEEE: Copy

    AHMAD GHORBANI, HASSAN RAKHSHANDEH, and HAMID REZA SADEGHNIA, “POTENTIATING EFFECTS OF LACTUCA SATIVA ON PENTOBARBITAL-INDUCED SLEEP,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 401–406, 2013, [Online]. Available: https://sid.ir/paper/288166/en

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