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Information Journal Paper

Title

CALIXTYROSOL: A NOVEL CALIXARENE BASED POTENT RADICAL SCAVENGER

Pages

  1181-1187

Abstract

 The oxidative stress causes many diseases in human, therefore ANTIOXIDANTs have a special position in the medicinal chemistry. TYROSOL is an important ANTIOXIDANT with a plenty of biological properties. There are many strategies such as clustering single drug units in order to develop new drugs. The cluster effect can increase drug effects relative to single drug unit. CALIXTYROSOL is the novel cluster of TYROSOL that shows a more effective ANTIOXIDANT activity than single TYROSOL. In fact, TYROSOL can be considered as 1/4 of the cluster.Four hydroxyethyl moieties have been grafted at the upper rim of the calix [4] arene in allsyn orientation, giving novel agent in the field of ANTIOXIDANT agents. Free RADICAL SCAVENGING tests were determined by the 2, 2-diphenyl-1-picrylhydrazyl radical in methanol for four ANTIOXIDANTs: CALIXTYROSOL, TYROSOL, hydroxytyrosol and 3, 5-di-tert-buty l-4-hydroxytoluene to compare their ANTIOXIDANT activity. Free RADICAL SCAVENGING test showed that CALIXTYROSOL has enhanced ANTIOXIDANT activity in comparison to the corresponding single TYROSOL unit (> 5 fold), it has even more active than the other test ANTIOXIDANTs (2 fold). Presumably, it is attributed to tethering and arraying of four impacted TYROSOL units, which make a synergistic effect in interactions with radicals for creating effective RADICAL SCAVENGING activity. This method is in debt of synergistic effect, tethering and arraying of single units in the cluster structure.

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    Cite

    APA: Copy

    NASUHI PURA, FAZEL, & AKBARI DILMAGHANI, KARIM. (2015). CALIXTYROSOL: A NOVEL CALIXARENE BASED POTENT RADICAL SCAVENGER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1181-1187. SID. https://sid.ir/paper/288398/en

    Vancouver: Copy

    NASUHI PURA FAZEL, AKBARI DILMAGHANI KARIM. CALIXTYROSOL: A NOVEL CALIXARENE BASED POTENT RADICAL SCAVENGER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1181-1187. Available from: https://sid.ir/paper/288398/en

    IEEE: Copy

    FAZEL NASUHI PURA, and KARIM AKBARI DILMAGHANI, “CALIXTYROSOL: A NOVEL CALIXARENE BASED POTENT RADICAL SCAVENGER,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1181–1187, 2015, [Online]. Available: https://sid.ir/paper/288398/en

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