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Information Journal Paper

Title

SCREENING OF DIFFERENT ETRACTS FROM ARTEMISIA SPECIES FOR THEIR POTENTIAL ANTIMALARIAL ACTIVITY

Pages

  603-608

Abstract

 The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for Antimalarial screening programs. In this study, we used an improved, cost-effective and highthroughput spectrophotometric assay to screen plant extracts for finding novel Antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis and A. turanica, were assessed for their Antimalarial activity by invitro β;-hematin formation assay. The most potent effect was observed in dichloromethane (DCM) extract of A. ciniformis with IC50 and IC90 values of 0. 92 ± 0. 01 and 1. 29 ± 0. 02 mg/ mL, respectively. Ethyl acetate (EtOAC) extracts of A. biennis and A. turanica also showed significant Antimalarial activities with IC50 values of 1. 11 ± 0. 02 and 1. 35 ± 0. 08 mg/mL and IC90 values of 1. 22 ± 0. 04 and 2. 81 ± 0. 21 mg/mL, respectively. Based on these results, it is possible to conclude that the components with strong Antimalarial activity have been concentrated in the medium-polar extracts.

Cites

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    • Cite

    APA: Copy

    MOJARRAB, MAHDI, NADERI, Rozhin, & HESHMATI AFSHAR, FARIBA. (2015). SCREENING OF DIFFERENT ETRACTS FROM ARTEMISIA SPECIES FOR THEIR POTENTIAL ANTIMALARIAL ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 603-608. SID. https://sid.ir/paper/288447/en

    Vancouver: Copy

    MOJARRAB MAHDI, NADERI Rozhin, HESHMATI AFSHAR FARIBA. SCREENING OF DIFFERENT ETRACTS FROM ARTEMISIA SPECIES FOR THEIR POTENTIAL ANTIMALARIAL ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):603-608. Available from: https://sid.ir/paper/288447/en

    IEEE: Copy

    MAHDI MOJARRAB, Rozhin NADERI, and FARIBA HESHMATI AFSHAR, “SCREENING OF DIFFERENT ETRACTS FROM ARTEMISIA SPECIES FOR THEIR POTENTIAL ANTIMALARIAL ACTIVITY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 603–608, 2015, [Online]. Available: https://sid.ir/paper/288447/en

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